Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity

Staines, Katherine; Hopkinson, Mark; Dillon, Scott; Stephen, Louise; Fleming, Robert; Sophocleous, Antonia; Buttle, David; Pitsillides, Andrew; Farquharson, Colin

Abstract

E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modeling/remodeling, through the production of the receptor for receptor activator of nuclear factor κB (RANK)-ligand (RANKL). Despite this, the role of Pdpn in the control of bone remodeling is yet to be established in vivo. Here we utilised bone-specific Pdpn conditional knockout mice (cKO) to examine the role of Pdpn in the bone loss associated with ovariectomy (OVX). MicroCT revealed that Pdpn deletion had no significant effect on OVX-induced changes in trabecular microarchitecture. Significant differences between genotypes were observed in the trabecular pattern factor (P

• Journal Article Type: Article
• Acceptance Date: Dec 23, 2019
• Publication Date: Jan 10, 2020
• Deposit Date: Jan 2, 2020
• Publicly Available Date: Jan 6, 2020
• Print ISSN: 0144-8463
• Electronic ISSN: 1573-4935
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 1
• DOI: https://doi.org/10.1042/BSR20190329
• Keywords: bone, E11/podoplanin, osteoclast, osteocyte, osteoporosis
• Public URL: http://researchrepository.napier.ac.uk/Output/2442586