New developments in osteoarthritis and cartilage biology

Poulet, Blandine; Staines, Katherine A

Abstract

Osteoarthritis (OA) is a degenerative joint disease and the most common form of arthritis. Characterised by articular cartilage loss, subchondral bone thickening and osteophyte formation, the OA joint afflicts much pain and disability. Whilst OA has been associated with many contributing factors, its underpinning molecular mechanisms are, nevertheless, not fully understood. Clinical management of OA is largely palliative and there is an ever growing need for an effective disease modifying treatment. This review discusses some of the recent progress in OA therapies in the different joint tissues affected by OA pathology.

Citation

Poulet, B., & Staines, K. A. (2016). New developments in osteoarthritis and cartilage biology. Current Opinion in Pharmacology, 28, 8-13. https://doi.org/10.1016/j.coph.2016.02.009

• Journal Article Type: Article
• Online Publication Date: Feb 26, 2016
• Publication Date: 2016-06
• Deposit Date: Jan 13, 2017
• Publicly Available Date: Nov 22, 2019
• Journal: Current Opinion in Pharmacology
• Print ISSN: 1471-4892
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Pages: 8-13
• DOI: https://doi.org/10.1016/j.coph.2016.02.009
• Keywords: Pharmacology; Drug Discovery
• Public URL: http://researchrepository.napier.ac.uk/Output/462363