Photocontrolled binding and binding-controlled photochromism within anthracene-modified DNA

Manchester, Jack; Bassani, Dario M; Duprey, Jean-Louis H A; Giordano, Luciana; Vyle, Joseph S; Zhao, Zheng-yun; Tucker, James H R

Abstract

Modified DNA strands undergo a reversible light-induced reaction involving the intramolecular photodimerization of two appended anthracene tags. The photodimers exhibit markedly different binding behavior toward a complementary strand that depends on the
number of bases between the modified positions. By preforming the duplex, photochromism can be suppressed, illustrating dual-mode gated behavior.

Citation

Manchester, J., Bassani, D. M., Duprey, J. H. A., Giordano, L., Vyle, J. S., Zhao, Z., & Tucker, J. H. R. (2012). Photocontrolled binding and binding-controlled photochromism within anthracene-modified DNA. Journal of the American Chemical Society, 134, 10791-10794. https://doi.org/10.1021/ja304205m

• Journal Article Type: Article
• Publication Date: 2012
• Deposit Date: Apr 10, 2014
• Print ISSN: 0002-7863
• Electronic ISSN: 1520-5126
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 134
• Pages: 10791-10794
• DOI: https://doi.org/10.1021/ja304205m
• Keywords: Modified DNA strands; light-induced reaction; intramolecular photodimerization; photodimers; binding behaviour
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/6768
• Publisher URL: http://dx.doi.org/10.1021/ja304205m