Bryan McIntosh
The highest mountain: T-cell technology
McIntosh, Bryan; Fascia, Michael
Abstract
T-lymphocytes (T-cell) therapy offers a treatment for cancers. Developing this technology in the future provides the opportunity to revolutionise treatment and to make cancer a chronic condition. T-cells in themselves are a type of lymphocytes (itself a type of white blood cell) that play a central role in cell mediated immunity. They can be distinguished from other lymphocytes, such as B-cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. T-cells have the capacity to destroy diseased cells, but tumours present a considerable challenge that reduces their impact. As cancer cells are frequently ‘invisible’ to the immune system, and they create an environment that suppresses T-cell activity., genetic engineering of T-cells can be used therapeutically to overcome these challenges. T-cells can be taken from the blood of cancer patients and then modified to recognise and destroy cancer-specific antigens.
Citation
McIntosh, B., & Fascia, M. (2014). The highest mountain: T-cell technology. British Journal of Healthcare Management, 20(6), 281-285. https://doi.org/10.12968/bjhc.2014.20.6.281
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 6, 2014 |
Online Publication Date | Jun 24, 2014 |
Publication Date | 2014-06 |
Deposit Date | Mar 15, 2018 |
Journal | British Journal of Healthcare Management |
Print ISSN | 1358-0574 |
Electronic ISSN | 1759-7382 |
Publisher | Mark Allen Healthcare |
Peer Reviewed | Peer Reviewed |
Volume | 20 |
Issue | 6 |
Pages | 281-285 |
DOI | https://doi.org/10.12968/bjhc.2014.20.6.281 |
Keywords | Cancer, leukaemia, T-cells, immunosuppression |
Public URL | http://researchrepository.napier.ac.uk/Output/1121377 |
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