Outputs (3)

Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis (2019)
Journal Article
Donnellan, S., Aljayyoussi, G., Moyo, E., Ardrey, A., Martinez-Rodriguez, C., Ward, S. A., & Biagini, G. A. (2020). Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis. Antimicrobial Agents and Chemotherapy, 64(1), https://doi.org/10.1128/aac.00989-19

Clinical studies of new antitubercular drugs are costly and time-consuming. Owing to the extensive tuberculosis (TB) treatment periods, the ability to identify drug candidates based on their predicted clinical efficacy is vital to accelerate the pipe... Read More about Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis.

Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis (2019)
Journal Article
Donnellan, S., & Giardiello, M. (2019). Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis. Journal of Interdisciplinary Nanomedicine, 4(3), 76-85. https://doi.org/10.1002/jin2.61

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes the most human deaths than any other diseases from a single infectious agent. Treatments are long and costly and have many associated side effects. Intracellular bacilli are slow g... Read More about Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis.

Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing (2019)
Journal Article
Aljayyoussi, G., Donnellan, S., Ward, S. A., & Biagini, G. A. (2019). Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing. Pharmaceutics, 11(6), Article 278. https://doi.org/10.3390/pharmaceutics11060278

Increasing rifampicin (RIF) dosages could significantly reduce tuberculosis (TB) treatment durations. Understanding the pharmacokinetic-pharmacodynamics (PK–PD) of increasing RIF dosages could inform clinical regimen selection. We used intracellular... Read More about Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing.