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Molecular detection of Chlamydia-like organisms in cattle drinking water (2011)
Journal Article
Wheelhouse, N., Saita, M., Gidlow, J., Deuchande, R., Borel, N., Baily, J., Caldow, G., & Longbottom, D. (2011). Molecular detection of Chlamydia-like organisms in cattle drinking water. Veterinary Microbiology, 152(1-2), 196-199. https://doi.org/10.1016/j.vetmic.2011.03.040

A substantial proportion of the causes of infectious bovine abortion remain largely undiagnosed, potentially due to the presence of previously unrecognised infectious agents. Recently, several reports have demonstrated the presence of Parachlamydia s... Read More about Molecular detection of Chlamydia-like organisms in cattle drinking water.

Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes (2011)
Journal Article
Saita, M., Clarka, E. M., Wheelhouse, N., Spalding, L., Livingstone, M., Sachse, K., Markey, B. K., Magnino, S., Siarkou, V. I., Vretou, E., Caro, M. R., Yaga, R., Lainson, F. A., Smith, D. G. E., Wright, F., & Longbottom, D. (2011). Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes. Veterinary Microbiology, 151(3-4), 284-290. https://doi.org/10.1016/j.vetmic.2011.03.005

This study used PCR-RFLP to investigate the genetic variability of pmp-encoding genes from fifty-two Chlamydophila abortus (C. abortus) strains originating from abortion cases from various geographical regions and host species. Six primer pairs were... Read More about Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes.

Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy (2010)
Journal Article
Shaw, J. L. V., Wills, G. S., Lee, K.-F., Horner, P. J., McClure, M. O., Abrahams, V. M., Wheelhouse, N., Jabbour, H. N., Critchley, H. O. D., Entrican, G., & Horne, A. W. (2011). Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy. American Journal of Pathology, 178(1), 253-260. https://doi.org/10.1016/j.ajpath.2010.11.019

Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. Fallopian tube (FT) from women with EP exhibit altered expression of prokine... Read More about Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy.

Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression (2010)
Journal Article
Fitch, P., Wheelhouse, N., Bowles, P., Paterson, M., Longbottom, D., Entrican, G., & Howie, S. (2010). Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression. Clinical and Experimental Immunology, 162(2), 372-378. https://doi.org/10.1111/j.1365-2249.2010.04231.x

Infection with Chlamydia pneumoniae (Cp) accounts for around 10% of community acquired bacterial pneumonia and has been associated with other chronic inflammatory conditions. We describe a C57/Bl6 murine model of Cp lung infection characterized by a... Read More about Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression.

Immunological paradigms and the pathogenesis of ovine chlamydial abortion (2010)
Journal Article
Entrican, G., Wattegedera, S., Wheelhouse, N., Allan, A., & Rocchi, M. (2010). Immunological paradigms and the pathogenesis of ovine chlamydial abortion. American Journal of Reproductive Immunology, 64(4), 287-294. https://doi.org/10.1111/j.1600-0897.2010.00907.x

Successful mammalian pregnancy involves complex immunological interactions between the mother and foetus that are not yet fully understood. A number of immunological paradigms have been established to explain the failure of the maternal immune system... Read More about Immunological paradigms and the pathogenesis of ovine chlamydial abortion.

Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube (2010)
Journal Article
Duncan, W. C., McDonald, S. E., Dickinson, R. E., Shaw, J. L. V., Lourenco, P. C., Wheelhouse, N., Lee, K.-F., Critchley, H. O. D., & Horne, A. W. (2010). Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Molecular Human Reproduction, 16, 950-959. https://doi.org/10.1093/molehr/gaq055

We investigated whether the repulsive SLIT/ROBO pathway is expressed in the endometrium and is negatively regulated during implantation. We also examined whether deficient expression in the Fallopian tube (FT) may predispose to ectopic pregnancy (EP)... Read More about Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube.

Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion (2010)
Journal Article
Wheelhouse, N., Aitchison, K., Laroucau, K., Thomson, J., & Longbottom, D. (2010). Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion. Vaccine, 28(35), 5657-5663. https://doi.org/10.1016/j.vaccine.2010.04.114

Chlamydophila abortus, the agent of ovine enzootic abortion (OEA), is a major cause of lamb mortality worldwide. Disease can be controlled through the use of vaccines based on the 1B temperature-sensitive mutant strain of C. abortus. This study inves... Read More about Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion.

Inflammatory cytokine responses in a pregnant mouse model of Chlamydophila abortus infection (2010)
Journal Article
Kerr, K., Wheelhouse, N., Livingstone, M., Anderson, I. E., Entrican, G., McKeever, D., & Longbottom, D. (2010). Inflammatory cytokine responses in a pregnant mouse model of Chlamydophila abortus infection. Veterinary Microbiology, 144(3-4), 392-398. https://doi.org/10.1016/j.vetmic.2010.01.025

Chlamydophila abortus (C. abortus) is the aetiological agent of ovine enzootic abortion (OEA). The highly elevated expression of the pro-inflammatory cytokine tumour necrosis factor-alpha (TNFα) and low-level expression of interferon-gamma (IFNγ) tha... Read More about Inflammatory cytokine responses in a pregnant mouse model of Chlamydophila abortus infection.