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Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes (2014)
Journal Article
Sait, M., Livingstone, M., Clark, E. M., Wheelhouse, N., Spalding, L., Markey, B., Magnino, S., Lainson, F. A., Myers, G. S. A., & Longbottom, D. (2014). Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes. BMC Genomics, 15, 23. https://doi.org/10.1186/1471-2164-15-23

BACKGROUND: Chlamydia pecorum is the causative agent of a number of acute diseases, but most often causes persistent, subclinical infection in ruminants, swine and birds. In this study, the genome sequences of three C. pecorum strains isolated from t... Read More about Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes.

Risk factors associated with Lawsonia intracellularis in English pig farms (2013)
Journal Article
Bae, J. K., Wieland, B., Sait, M., Longbottom, D., Smith, D. G. E., Alarcon, P., & Wheelhouse, N. (2013). Risk factors associated with Lawsonia intracellularis in English pig farms. Veterinary Journal, 197(3), 707-711. https://doi.org/10.1016/j.tvjl.2013.03.020

Porcine proliferative enteropathy (PPE) caused by the bacterium Lawsonia intracellularis causes considerable economic loss to the pig industry. The objective of this study was to evaluate the seroprevalence of L. intracellularis exposure in different... Read More about Risk factors associated with Lawsonia intracellularis in English pig farms.

Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep (2013)
Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., Wheelhouse, N., Dagleish, M., Aitchison, K., Wattegedera, S., Nath, M., Entrican, G., & Buxton, D. (2013). Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), Article e57950. https://doi.org/10.1371/journal.pone.0057950

BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy. Often the first sign that an animal is infected is ab... Read More about Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep.

Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle (2012)
Journal Article
Longbottom, D., Wheelhouse, N., Sait, M., Wilson, K., Aitchison, K., McLean, K., & Smith, D. G. E. (2012). Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle. Veterinary Microbiology, 160(3-4), 525-529. https://doi.org/10.1016/j.vetmic.2012.06.017

It has been suggested that polymorphic membrane proteins (Pmps) belonging to the Type V autotransporter protein family play an important role in the pathogenesis of Chlamydia abortus (C. abortus; formerly Chlamydophila abortus) infection. In a previo... Read More about Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle.

Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle (2012)
Journal Article
Wheelhouse, N. M., Sait, M., Aitchison, K., Livingstone, M., Wright, F., McLean, K., Inglis, N. F., Smith, D. G. E., & Longbottom, D. (2012). Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle. PLOS ONE, 7, Article e49190. https://doi.org/10.1371/journal.pone.0049190

BACKGROUND: Chlamydia possess a unique family of autotransporter proteins known as the Polymorphic membrane proteins (Pmps). While the total number of pmp genes varies between Chlamydia species, all encode a single pmpD gene. In both Chlamydia tracho... Read More about Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle.

Evaluation of the impact and control of enzootic abortion of ewes (2012)
Journal Article
Longbottom, D., Entrican, G., Wheelhouse, N., Brough, H., & Milne, C. (2013). Evaluation of the impact and control of enzootic abortion of ewes. Veterinary Journal, 195(2), 257-259. https://doi.org/10.1016/j.tvjl.2012.06.018

Despite the availability of effective management and treatment strategies, Chlamydia abortus remains the single most frequently diagnosed cause of infectious ovine abortion (enzootic abortion of ewes, EAE) in the UK and one of the most significant ca... Read More about Evaluation of the impact and control of enzootic abortion of ewes.

Involvement of Parachlamydia in bovine abortions in Scotland (2012)
Journal Article
Howie, F., Gidlow, J., Greub, G., Wheelhouse, N., Dagleish, M., & Longbottom, D. (2012). Involvement of Parachlamydia in bovine abortions in Scotland. Veterinary Journal, 193(2), 586-588. https://doi.org/10.1016/j.tvjl.2012.01.008

Bovine abortion represents a major animal welfare issue and a cause of substantial economic loss yet the rate of successful diagnosis remains low. Chlamydia-related organisms including Parachlamydia have recently emerged as putative cattle abortifaci... Read More about Involvement of Parachlamydia in bovine abortions in Scotland.

New challenges for vaccination to prevent chlamydial abortion in sheep (2011)
Journal Article
Entrican, G., Wheelhouse, N., Wattegedera, S. R., & Longbottom, D. (2012). New challenges for vaccination to prevent chlamydial abortion in sheep. Comparative Immunology, Microbiology and Infectious Diseases, 35(3), 271-276. https://doi.org/10.1016/j.cimid.2011.12.001

Ovine enzootic abortion (OEA) is caused by the obligate intracellular Gram-negative bacterium Chlamydia abortus. OEA remains a common cause of infectious abortion in many sheep-rearing countries despite the existence of commercially available vaccine... Read More about New challenges for vaccination to prevent chlamydial abortion in sheep.

Endemic and emerging chlamydial infections of animals and their zoonotic implications (2011)
Journal Article
Wheelhouse, N., & Longbottom, D. (2011). Endemic and emerging chlamydial infections of animals and their zoonotic implications. Transboundary and Emerging Diseases, 59(4), 283-291. https://doi.org/10.1111/j.1865-1682.2011.01274.x

The Chlamydiae are a diverse group of obligate intracellular Gram-negative bacteria that are known to infect a wide variety of host species and are responsible for a wide range of diseases in animals and man. Many of these organisms have been extensi... Read More about Endemic and emerging chlamydial infections of animals and their zoonotic implications.