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Outputs (71)

Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS) (2025)
Presentation / Conference Contribution
Wang, Y., McCredie, R., Rae, M., Cahill, A., Duncan, C., & Siemienowicz, K. (2025, May). Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS). Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Prenatally androgenised female sheep are a clinically realistic model of PCOS. In adolescence (11 months of age) there is reduced subcutaneous adipogenesis and in adulthood (30 months of age) there is increased subcutaneous adipose tissue (SAT) dysfu... Read More about Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS).

Excess adrenal androgen secretion is a consequence of in utero androgen excess in an ovine model of PCOS (2025)
Presentation / Conference Contribution
Rae, M., Ramaswamy, S., Siemienowicz, K., McNeilly, A., Howie, F., Wilson, K., Hogg, K., & Duncan, W. C. (2025, May). Excess adrenal androgen secretion is a consequence of in utero androgen excess in an ovine model of PCOS. Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Evidence for bone marrow adipose tissue dysfunction in polycystic ovary syndrome (PCOS) (2025)
Presentation / Conference Contribution
McCredie, R., Levate, G., Wang, Y., Rae, M., Duncan, C., & Siemienowicz, K. (2025, May). Evidence for bone marrow adipose tissue dysfunction in polycystic ovary syndrome (PCOS). Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

The effect of intranasal insulin on post prandial thermogenesis in obese women with and without polycystic ovary syndrome (2025)
Presentation / Conference Contribution
Duncan, C., Wang, Y., McCredie, R., Franks, S., Fowler, P., Stimson, R., Rae, M., & Siemienowicz, K. (2025, May). The effect of intranasal insulin on post prandial thermogenesis in obese women with and without polycystic ovary syndrome. Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS). (2024)
Journal Article
Levate, G., Wang, Y., McCredie, R., Fenwick, M., Rae, M. T., Duncan, W. C., & Siemienowicz, K. J. (2025). Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, 595, Article 112416. https://doi.org/10.1016/j.mce.2024.112416

Adipose tissue dysfunction is one of the features of Polycystic Ovary Syndrome (PCOS) with dysregulated adipogenesis, altered functional pathways and increased inflammation. It is increasingly clear that there are also male correlates of the hormonal... Read More about Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS)..

Pregnancy length and health in giant pandas: what can metabolic and urinary endocrine markers unveil? (2023)
Journal Article
Wauters, J., Wilson, K. S., Cools, T., Vancsok, C., Bouts, T., Mulot, B., Leclerc, A., Haapakoski, M., Kok, J., Kühne, R., Ochs, A., Duncan, W. C., Girling, S. J., Hildebrandt, T. B., Zhou, Q., Li, R., Zhou, Y., Cai, K., Liu, Y., Hou, R., …Li, D. (2023). Pregnancy length and health in giant pandas: what can metabolic and urinary endocrine markers unveil?. Theriogenology Wild, 3, Article 100063. https://doi.org/10.1016/j.therwi.2023.100063

Mature female giant pandas usually ovulate once a year. This is followed by an obligatory luteal phase, consisting of a long-lasting corpus luteum dormancy phase (CLD; primary increase in progestogens) and a much shorter active luteal phase (AL; seco... Read More about Pregnancy length and health in giant pandas: what can metabolic and urinary endocrine markers unveil?.

Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation (2023)
Journal Article
Duncan, W. C., Nicol, L. M., O’Hare, R., Witherington, J., Miranda, J. A., Campbell, B. K., Thomas, J. L., & Rae, M. T. (2023). Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation. Frontiers in Endocrinology, 14, Article 1285269. https://doi.org/10.3389/fendo.2023.1285269

Introduction: Polycystic ovary syndrome (PCOS) seems to be associated with increased ovarian sympathetic nerve activity and in rodent models of PCOS reducing the sympathetic drive to the ovary, through denervation or neuromodulation, improves ovulati... Read More about Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation.

Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males” (2022)
Journal Article
Siemienowicz, K. J., Filis, P., Thomas, J., Fowler, P. A., Duncan, W. C., & Rae, M. T. (2022). Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”. Biomedicines, 10(6), Article 1291. https://doi.org/10.3390/biomedicines10061291

First-degree male relatives of polycystic ovary syndrome (PCOS) sufferers can develop metabolic abnormalities evidenced by elevated circulating cholesterol and triglycerides, suggestive of a male PCOS equivalent. Similarly, male sheep overexposed to... Read More about Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”.

Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment (2022)
Presentation / Conference Contribution
Ross, B. L., Malone, E. M., Rae, M. T., Bouwmeester, H., van der Zande, M., & Hutchison, G. R. (2022, March). Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, California