Outputs (18)

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy (2019)
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., Barlow, P., & Stevens, C. (2019). The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), Article e0209665. https://doi.org/10.1371/journal.pone.0209665

The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively... Read More about The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

MS TCR Therapy (2018)
Patent
Wright, G., Stauss, H., & McGovern, J. MS TCR Therapy. United Kingdon

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., Chambers, G., & Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

Engineering Specificity and Function of Therapeutic Regulatory T Cells (2017)
Journal Article
McGovern, J. L., Wright, G. P., & Stauss, H. J. (2017). Engineering Specificity and Function of Therapeutic Regulatory T Cells. Frontiers in Immunology, 8, Article 1517. https://doi.org/10.3389/fimmu.2017.01517

Adoptive therapy with polyclonal regulatory T cells (Tregs) has shown efficacy in suppressing detrimental immune responses in experimental models of autoimmunity and transplantation. The lack of specificity is a potential limitation of Treg therapy,... Read More about Engineering Specificity and Function of Therapeutic Regulatory T Cells.

Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study (2017)
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Imber, C., Sharma, D., Malago, M., Fuller, B. J., & Davidson, B. R. (2017). Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study. HPB, 19(9), 757-767. https://doi.org/10.1016/j.hpb.2017.05.005

Background
Ischaemia Reperfusion (IR) injury is a major cause of morbidity, mortality and graft loss following Orthotopic Liver Transplantation (OLT). Utilising marginal grafts, which are more susceptible to IR injury, makes this a key research goal... Read More about Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study.

Recruitment of inflammatory monocytes after liver transplantation and correlation with clinical outcome (2017)
Presentation / Conference Contribution
Robertson, F., Male, V., Wright, G., Fuller, B., & Davidson, B. (2017, February). Recruitment of inflammatory monocytes after liver transplantation and correlation with clinical outcome

Background
Ischaemia reperfusion injury is a key cause of mortality and graft loss after liver transplantation. After tissue injury, monocytes are rapidly mobilised and recruited to injured tissue by monocyte chemoattractant protein-1 (MCP-1). Eleva... Read More about Recruitment of inflammatory monocytes after liver transplantation and correlation with clinical outcome.

A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation (2016)
Journal Article
Robertson, F. P., Magill, L. J., Wright, G. P., Fuller, B., & Davidson, B. R. (2016). A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation. Transplant International, 29(11), 1147-1154. https://doi.org/10.1111/tri.12849

Ischaemic preconditioning (IPC) is a strategy to reduce ischaemia–reperfusion (IR) injury. Its benefit in human liver transplantation is unclear. The aim of this study was to analyse the current evidence for donor IPC in liver transplantation. System... Read More about A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation.

Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial) (2016)
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Fuller, B., & Davidson, B. R. (2016). Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial). Transplantation Research, 5(1), https://doi.org/10.1186/s13737-016-0033-4

Ischaemic reperfusion (IR) injury is a major cause of graft loss, morbidity and mortality following orthotopic liver transplantation (OLT). Demand for liver transplantation has resulted in increasing use of marginal grafts that are more prone to IR i... Read More about Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial).

Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo (2013)
Journal Article
Xue, S.-A., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., Holler, A., Wright, G., Thomas, S., Topp, M., Morris, E. C., & Stauss, H. J. (2013). Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology, 2(1), Article e22590. https://doi.org/10.4161/onci.22590

In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma, nasopharyngeal carcinoma and medulloblastoma, respectively. Retroviral... Read More about Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo.

CD3 limits the efficacy of TCR gene therapy in vivo (2011)
Journal Article
Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., Waxman, J., Morris, E., & Stauss, H. J. (2011). CD3 limits the efficacy of TCR gene therapy in vivo. Blood, 118(13), 3528-3537. https://doi.org/10.1182/blood-2011-04-346338

The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR
/ heterodimer. We tested whether endogenous CD3 chains are rate-limiting for TCR expression and antigen-specific T-cell fu... Read More about CD3 limits the efficacy of TCR gene therapy in vivo.