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Outputs (26)

Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling (2024)
Preprint / Working Paper
Elsharkasi, M., Villani, B., Wells, G., & Kerr, F. Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling

As a gate-keeper of anti-oxidant, anti-inflammatory and xenobiotic cell protection mechanisms, the transcription factor Nrf2 has been implicated as a promising therapeutic target for several neurodegenerative diseases, leading to the development of N... Read More about Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling.

Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field [Version 2] (2022)
Journal Article
Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N., & Kerr, F. (2022). Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field [Version 2]. AMRC Open Research, 4, Article 22. https://doi.org/10.12688/amrcopenres.13091.2

Background
Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this end, formal mentorship programmes (where researchers are paired with one... Read More about Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field [Version 2].

Building a Systematic Online Living Evidence Summary of COVID-19 Research (2021)
Journal Article
Hair, K., Sena, E. S., Wilson, E., Currie, G., Macleod, M., Bahor, Z., Sena, C., Ayder, C., Liao, J., Tanriver Ayder, E., Ghanawi, J., Tsang, A., Collins, A., Carstairs, A., Antar, S., Drax, K., Neves, K., Ottavi, T., Chow, Y. Y., Henry, D., …Drury, B. (2021). Building a Systematic Online Living Evidence Summary of COVID-19 Research. Journal of the European Association for Health Information and Libraries, 17(2), 21-26. https://doi.org/10.32384/jeahil17465

Throughout the global coronavirus pandemic, we have seen an unprecedented volume of COVID-19 researchpublications. This vast body of evidence continues to grow, making it difficult for research users to keep up with the pace of evolving research find... Read More about Building a Systematic Online Living Evidence Summary of COVID-19 Research.

Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity (2021)
Journal Article
Niccoli, T., Kerr, F., Snoeren, I., Fabian, D., Aleyakpo, B., Ivanov, D., Sofola-Adesakin, O., Cryar, A., Adcott, J., Thornton, J., & Partridge, L. (2021). Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Communications, 3(2), Article fcab053. https://doi.org/10.1093/braincomms/fcab053

Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer’s disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in Drosophila models of amyloid beta 4... Read More about Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity.

Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila (2020)
Journal Article
Scholes, H. M., Cryar, A., Kerr, F., Sutherland, D., Gethings, L. A., Vissers, J. P. C., Lees, J. G., Orengo, C. A., Partridge, L., & Thalassinos, K. (2020). Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports, 10(1), Article 18517 (2020). https://doi.org/10.1038/s41598-020-74748-9

Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neurodegenerative condition for which there are no effective treatments. Understanding the molecular pathology of AD during disease progression may identi... Read More about Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila.

Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models (2018)
Journal Article
Kerr, F., Bjedov, I., & Sofola-Adesakin, O. (2018). Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models. Frontiers in Molecular Neuroscience, 11, Article 297. https://doi.org/10.3389/fnmol.2018.00297

Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium’s effectiveness for improving neurological function is therefore well-described, stimulating the investigat... Read More about Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models.

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease (2017)
Journal Article
Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Gomez Perez-Nievas, B., Bertrand, H. C., Martinez, P., Callard, R., Snoeren, I., Cochemé, H. M., Adcott, J., Khericha, M., Castillo-Quan, J. I., Wells, G., Noble, W., Thornton, J., & Partridge, L. (2017). Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLOS Genetics, 13(3), Article e1006593. https://doi.org/10.1371/journal.pgen.1006593

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway ove... Read More about Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease.