Projects (13)

Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease May 12, 2020 - Dec 31, 2021
Nrf2 activators show pre-clinical promise in the treatment of several neurodegenerative diseases, including Alzheimer’s disease (AD), but exert clinical toxicity. Nrf2 regulates hundreds of anti-oxidant response element (ARE)-containing genes, but th... Read More about Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease.

Enhancing the stability and the delivery of lactoferrin for prevention and/or treatment of covid-19 respiratory disease. Feb 14, 2022 - Nov 13, 2023
Lactoferrin (LF) is a glycoprotein which is widely contained in many secretory fluids, mainly milk but also saliva, tears, and nasal secretions. Many scientific reports supported an application of this glycoprotein in the prophylaxis and treatment of... Read More about Enhancing the stability and the delivery of lactoferrin for prevention and/or treatment of covid-19 respiratory disease..

Developing an adoptive regulatory T cell therapy for the treatment of rheumatoid arthritis Mar 1, 2021 - Feb 28, 2024
The immune system contains a balance of cells that turn responses ‘on’ and those that turn it ‘off’. When this balance breaks down, inappropriate immune responses can attack healthy tissues causing autoimmune disease, such as rheuma... Read More about Developing an adoptive regulatory T cell therapy for the treatment of rheumatoid arthritis.

Biochemical Society Summer Vacation Scholarship May 15, 2017 - Jul 10, 2017
Nrf2, a transcriptional activator of cell protection genes, is an emerging target for neurodegenerative conditions including Alzheimer’s disease (AD). Nrf2 activity is reduced in dementia patients and Nrf2 inducing compounds prevent neuronal damage i... Read More about Biochemical Society Summer Vacation Scholarship.

Medical Research Scotland Vacation Scholarship Jun 13, 2022 - Aug 8, 2023
Investigating the anti-metastatic potential of Honokiol by attenuating KISS1/ KISS1R signaling

Exploiting micofluidic devices for physiologically relavent drug screening against human pathogens  Jun 1, 2022 - Jul 27, 2022
Undergraduate student summer project (8 weeks)

Do iron-oxide nanoparticles contribute to Parkinsons Disease pathology? Oct 1, 2021 - Nov 21, 2022
Anthropogenic iron-oxide nanoparticles (IONPs) detected in ultrafine particulate matter caused by traffic and industrial emissions have increased substantially over time, constituting one of the most serious threats to human health. However, IONPs ha... Read More about Do iron-oxide nanoparticles contribute to Parkinsons Disease pathology?.

Covid-19 support scheme for Postdoctoral researchers 2021 Oct 1, 2021 - Dec 27, 2021
Covid-19 support scheme for Postdoctoral researchers 2021

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease Oct 1, 2019 - Dec 31, 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the immune system to reduce inflammation and induce remi... Read More about Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease.

Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection Apr 1, 2019 - Mar 31, 2022
A significant challenge faced by modern society is the lack of therapeutics for a large number of infections, particularly those that are endemic or widely spread in developing countries. Dengue is one such infection which is endemic inIndonesia - it... Read More about Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection.

IBD drug effect on autophagy (IDEA) Oct 1, 2017 - Mar 31, 2018
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD

Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis Sep 1, 2018 - Apr 30, 2023
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately produces pain and the impairment of normal activities... Read More about Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis.

An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD Sep 1, 2014 - Aug 31, 2017
Recent genetic discoveries, principally identification of NOD2 and ATG16L1 as susceptibility loci, strongly implicate a dysregulated host response to enteric bacteria and the autophagy pathway in the pathogenesis of Crohn’s disease (CD). Several micr... Read More about An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD.