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Dr Kasia Siemienowicz's Outputs (16)

Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS). (2024)
Journal Article
Levate, G., Wang, Y., McCredie, R., Fenwick, M., Rae, M. T., Duncan, W. C., & Siemienowicz, K. J. (online). Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, Article 112416. https://doi.org/10.1016/j.mce.2024.112416

Adipose tissue dysfunction is one of the features of Polycystic Ovary Syndrome (PCOS) with dysregulated adipogenesis, altered functional pathways and increased inflammation. It is increasingly clear that there are also male correlates of the hormonal... Read More about Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS)..

Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males” (2022)
Journal Article
Siemienowicz, K. J., Filis, P., Thomas, J., Fowler, P. A., Duncan, W. C., & Rae, M. T. (2022). Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”. Biomedicines, 10(6), Article 1291. https://doi.org/10.3390/biomedicines10061291

First-degree male relatives of polycystic ovary syndrome (PCOS) sufferers can develop metabolic abnormalities evidenced by elevated circulating cholesterol and triglycerides, suggestive of a male PCOS equivalent. Similarly, male sheep overexposed to... Read More about Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”.

Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome (2021)
Journal Article
Siemienowicz, K. J., Furmanska, K., Filis, P., Talia, C., Thomas, J., Fowler, P. A., Rae, M. T., & Colin Duncan, W. (2021). Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Molecular and Cellular Endocrinology, 525, Article 111196. https://doi.org/10.1016/j.mce.2021.111196

Polycystic ovary syndrome (PCOS), affecting over 10% of women, is associated with insulin resistance, obesity, dyslipidaemia, fatty liver and adipose tissue dysfunction. Its pathogenesis is poorly understood and consequently treatment remains subopti... Read More about Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome.

Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses (2020)
Journal Article
Siemienowicz, K. J., Wang, Y., Marečková, M., Nio-Kobayashi, J., Fowler, P. A., Rae, M. T., & Duncan, W. C. (2020). Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-78976-x

Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in... Read More about Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses.

Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS) (2020)
Journal Article
Siemienowicz, K. J., Coukan, F., Franks, S., Rae, M. T., & Colin Duncan, W. (2021). Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, 519, Article 111042. https://doi.org/10.1016/j.mce.2020.111042

Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and increased adiposity are key factors contributing to metabolic dysfunction in PCOS. We hypothesised that aberrant adipogenesis duri... Read More about Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS).

Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS) (2020)
Journal Article
Siemienowicz, K., Rae, M. T., Howells, F., Anderson, C., Nicol, L. M., Franks, S., & Duncan, W. C. (2020). Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS). iScience, 23(6), Article 101164. https://doi.org/10.1016/j.isci.2020.101164

Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energy expenditure. We used a clinically-realistic preclinical model to investig... Read More about Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS).

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life (2019)
Presentation / Conference Contribution
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., Fowler, P., Duncan, C., & Rae, M. (2019, May). Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Presented at 21st European Congress of Endocrinology, Lyon, France

Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), and hyperinsulinaemia. As altered intrauterine endocrine environments can ‘... Read More about Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life.

Fetal androgen exposure is a determinant of adult male metabolic health (2019)
Journal Article
Siemienowicz, K. J., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., Howie, F., Fowler, P. A., Duncan, W. C., & Rae, M. T. (2019). Fetal androgen exposure is a determinant of adult male metabolic health. Scientific Reports, 9, Article 20195 (2019). https://doi.org/10.1038/s41598-019-56790-4

Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypothesised that poor adult male health was partially attributable to aberrant... Read More about Fetal androgen exposure is a determinant of adult male metabolic health.

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS) (2016)
Presentation / Conference Contribution
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, July). Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS). Paper presented at Society for Reproduction and Fertility Annual Conference, Winchester

Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion (2016)
Journal Article
Ramaswamy, S., McNeilly, A. S., Rae, M. T., Ramaswamy, S., Grace, C., Mattei, A. A., Siemienowicz, K., Brownlee, W., MacCallum, J., McNeilly, A. S., Duncan, W. C., & Rae, M. T. (2016). Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion. Scientific Reports, 6(1), Article 27408. https://doi.org/10.1038/srep27408

Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fetuses at d62 and d82 of gestation, and examined fetal (day 90 gestation) and... Read More about Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion.

Altered adipocytes in an ovine model of polycystic ovary syndrome (2015)
Presentation / Conference Contribution
Siemienowicz, K., Couckan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2015, November). Altered adipocytes in an ovine model of polycystic ovary syndrome. Poster presented at Society for Endocrinology BES, Edinburgh

Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure (2015)
Presentation / Conference Contribution
Siemienowicz, K., Rae, M., Lerner, A., Franks, S., & Duncan, C. (2015, July). Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure. Paper presented at Society for Reproduction and Fertility Annual Conference

Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance and obesity. Obesity is associated with increased energy intake or reduced... Read More about Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure.

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome (2014)
Presentation / Conference Contribution
Siemienowicz, K., Boswell, L., Carr, D., Mina, T., Connolly, F., Rae, M., & Duncan, C. (2014, May). The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome. Poster presented at 16th European Congress of Endocrinology, Wroclaw, Poland

Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hepatic IGF1. The aim of this study was to investigate the molecular pathophys... Read More about The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome.