Dr Fiona Kerr's Projects (4)

Defining how the balance of glial homeostasis and inflammation drives brain ageing and neurodegeneration Jul 1, 2025 - Jun 30, 2028
This project aims to enable novel therapies for age-related neurodegenerative diseases by prioritising and defining the molecular mechanisms by which recently identified putative age-related genes are significantly enriched in homeostatic glial proce... Read More about Defining how the balance of glial homeostasis and inflammation drives brain ageing and neurodegeneration.

Do iron-oxide nanoparticles contribute to Parkinsons Disease pathology? Oct 1, 2021 - Nov 21, 2022
Anthropogenic iron-oxide nanoparticles (IONPs) detected in ultrafine particulate matter caused by traffic and industrial emissions have increased substantially over time, constituting one of the most serious threats to human health. However, IONPs ha... Read More about Do iron-oxide nanoparticles contribute to Parkinsons Disease pathology?.

Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease May 12, 2020 - Dec 31, 2021
Nrf2 activators show pre-clinical promise in the treatment of several neurodegenerative diseases, including Alzheimer’s disease (AD), but exert clinical toxicity. Nrf2 regulates hundreds of anti-oxidant response element (ARE)-containing genes, but th... Read More about Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease.

Biochemical Society Summer Vacation Scholarship May 15, 2017 - Jul 10, 2017
Nrf2, a transcriptional activator of cell protection genes, is an emerging target for neurodegenerative conditions including Alzheimer’s disease (AD). Nrf2 activity is reduced in dementia patients and Nrf2 inducing compounds prevent neuronal damage i... Read More about Biochemical Society Summer Vacation Scholarship.