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Protocols for Understanding the Redox Behavior of Copper-Containing Systems (2022)
Journal Article
Malcomson, T., Repiščák, P., Erhardt, S., & Paterson, M. J. (2022). Protocols for Understanding the Redox Behavior of Copper-Containing Systems. ACS Omega, 7(49), 45057-45066. https://doi.org/10.1021/acsomega.2c05484

Suitability of single-reference density functional theory (DFT) methods for the calculation of redox potentials of copper-containing macrocycle complexes was confirmed by the use of T 1 diagnostics along with a verification of negligible spin contami... Read More about Protocols for Understanding the Redox Behavior of Copper-Containing Systems.

Metformin selectively targets redox control of complex I energy transduction (2017)
Journal Article
Cameron, A. R., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J. T., Kerr, C., Curry, H., Stewart, D., Sakamoto, K., Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G., & Rena, G. (2018). Metformin selectively targets redox control of complex I energy transduction. Redox Biology, 14, 187-197. https://doi.org/10.1016/j.redox.2017.08.018

Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that... Read More about Metformin selectively targets redox control of complex I energy transduction.