PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity
(2019)
Journal Article
Siddiqui, F. A., Alam, C., Ora, M., Sabt, A., Manoharan, G. B., Bindu, L., …Abankwa, D. (2020). PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity. ACS Omega, 5(1), 832-842. https://doi.org/10.1021/acsomega.9b03639
The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and t... Read More about PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity.