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All Outputs (258)

Exosomes as mediators of cell-to-cell communication in prostate cancer (2021)
Thesis
Bruce, I. Exosomes as mediators of cell-to-cell communication in prostate cancer. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2803794

Prostate cancer (PCa) is dependent on androgens for growth. Androgen deprivation therapy (ADT) curtails PCa progression, however this powerful selective pressure leads to aggressive, castrate resistant PCa. One castrate resistant prostate cancer subt... Read More about Exosomes as mediators of cell-to-cell communication in prostate cancer.

Design, synthesis and evaluation of novel and clinically used anti-cancer agents targeted intracellularly (2021)
Thesis
Mohammed, O. Design, synthesis and evaluation of novel and clinically used anti-cancer agents targeted intracellularly. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2799744

The development of drug resistance, notably multidrug resistance (MDR) and adverse side effects due to treatment with current anticancer drugs are considerable obstacles in cancer therapy and together with dose-limiting toxicity lead to therapeutic f... Read More about Design, synthesis and evaluation of novel and clinically used anti-cancer agents targeted intracellularly.

Fatigue and the mind-body relation: a Lacanian exploration (2021)
Thesis
Diserholt, A. Fatigue and the mind-body relation: a Lacanian exploration. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2701703

This thesis explores the symptomatology of fatigue based on interviews conducted with seven people who are diagnosed with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. The thesis starts by examining how a biomedical view of fatigue — the domina... Read More about Fatigue and the mind-body relation: a Lacanian exploration.

Understanding the housing of asylum seekers and refugees during the Covid-19 outbreak (2021)
Presentation / Conference Contribution
Guma, T., Sharapov, K., Blake, Y., Makutsa, R., Maclean, G., & Macleod, K. (2021, July). Understanding the housing of asylum seekers and refugees during the Covid-19 outbreak. Paper presented at Disrupting Theory, Unsettling Practice: Towards Transformative Forced Migration Scholarship and Policy, University of Ghana

Paper presented at Disrupting Theory, Unsettling Practice: Towards Transformative Forced Migration Scholarship and Policy, University of Ghana, 26-30 July 2021.

A functional analysis reveals extremely low redundancy in global mangrove invertebrate fauna (2021)
Journal Article
Cannicci, S., Lee, S. Y., Bravo, H., Cantera-Kintz, J. R., Dahdouh-Guebas, F., Fratini, S., Fusi, M., Jimenez, P. J., Nordhaus, I., Porri, F., & Diele, K. (2021). A functional analysis reveals extremely low redundancy in global mangrove invertebrate fauna. Proceedings of the National Academy of Sciences, 118(32), Article e2016913118. https://doi.org/10.1073/pnas.2016913118

Deforestation results in habitat fragmentation, decreasing diversity, and functional degradation. For mangroves, no data are available on the impact of deforestation on the diversity and functionality of the specialized invertebrate fauna, critical f... Read More about A functional analysis reveals extremely low redundancy in global mangrove invertebrate fauna.

Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes (2021)
Journal Article
Alam, C. M., Baghestani, S., Pajari, A., Omary, M. B., & Toivola, D. M. (2021). Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes. International Journal of Molecular Sciences, 22(15), Article 7784. https://doi.org/10.3390/ijms22157784

Keratin (K) 7 is an intermediate filament protein expressed in ducts and glands of simple epithelial organs and in urothelial tissues. In the pancreas, K7 is expressed in exocrine ducts, and apico-laterally in acinar cells. Here, we report K7 express... Read More about Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes.

Epidemiology of healthcare-associated infection reported from a hospital-wide incidence study: considerations for infection prevention and control planning (2021)
Journal Article
Stewart, S., Robertson, C., Pan, J., Kennedy, S., Dancer, S., Haahr, L., Manoukian, S., Mason, H., Kavanagh, K., Cook, B., & Reilly, J. (2021). Epidemiology of healthcare-associated infection reported from a hospital-wide incidence study: considerations for infection prevention and control planning. Journal of Hospital Infection, 114, 10-22. https://doi.org/10.1016/j.jhin.2021.03.031

Background The measure of disease frequency most widely used to report healthcare-associated infection (HAI) is the point-prevalence survey. Incidence studies are rarely performed due to time and cost constraints; they show which patients are affect... Read More about Epidemiology of healthcare-associated infection reported from a hospital-wide incidence study: considerations for infection prevention and control planning.

Impact of healthcare-associated infection on length of stay (2021)
Journal Article
Stewart, S., Robertson, C., Pan, J., Kennedy, S., Haahr, L., Manoukian, S., Mason, H., Kavanagh, K., Graves, N., Dancer, S., Cook, B., & Reilly, J. (2021). Impact of healthcare-associated infection on length of stay. Journal of Hospital Infection, 114, 23-31. https://doi.org/10.1016/j.jhin.2021.02.026

Background Increased length of stay (LOS) for patients is an important measure of the burden of healthcare-associated infection (HAI). Aim To estimate the excess LOS attributable to HAI. Methods This was a one-year prospective incidence study of... Read More about Impact of healthcare-associated infection on length of stay.

Personalized infection prevention and control: dentifying patients at risk of healthcare-associated infection (2021)
Journal Article
Stewart, S., Robertson, C., Kennedy, S., Kavanagh, K., Haahr, L., Manoukian, S., Mason, H., Dancer, S., Cook, B., & Reilly, J. (2021). Personalized infection prevention and control: dentifying patients at risk of healthcare-associated infection. Journal of Hospital Infection, 114, 32-42. https://doi.org/10.1016/j.jhin.2021.03.032

Background Few healthcare-associated infection (HAI) studies focus on risk of HAI at the point of admission. Understanding this will enable planning and management of care with infection prevention at the heart of the patient journey from the point... Read More about Personalized infection prevention and control: dentifying patients at risk of healthcare-associated infection.

Bed-days and costs associated with the inpatient burden of healthcare-associated infection in the UK (2021)
Journal Article
Manoukian, S., Stewart, S., Graves, N., Mason, H., Robertson, C., Kennedy, S., Pan, J., Kavanagh, K., Haahr, L., Adil, M., Dancer, S., Cook, B., & Reilly, J. (2021). Bed-days and costs associated with the inpatient burden of healthcare-associated infection in the UK. Journal of Hospital Infection, 114, 43-50. https://doi.org/10.1016/j.jhin.2020.12.027

Background Healthcare-associated infection (HAI) is associated with increased morbidity and mortality resulting in excess costs. Aim To investigate the impact of all types of HAI on the inpatient cost of HAI using different approaches. Methods T... Read More about Bed-days and costs associated with the inpatient burden of healthcare-associated infection in the UK.

Evaluating the post-discharge cost of healthcare-associated infection in NHS Scotland (2021)
Journal Article
Manoukian, S., Stewart, S., Graves, N., Mason, H., Robertson, C., Kennedy, S., Pan, J., Haahr, L., Dancer, S., Cook, B., & Reilly, J. (2021). Evaluating the post-discharge cost of healthcare-associated infection in NHS Scotland. Journal of Hospital Infection, 114, 51-58. https://doi.org/10.1016/j.jhin.2020.12.026

Background Whereas the cost burden of healthcare-associated infection (HAI) extends beyond the inpatient stay into the post-discharge period, few studies have focused on post-discharge costs. Aim To investigate the impact of all types of HAI on... Read More about Evaluating the post-discharge cost of healthcare-associated infection in NHS Scotland.

Locked Down, Locked Out?: Local Partnership Resilience in the Covid-19 Pandemic - A Report on Interim Findings (2021)
Report
Buchan, J., Nogales, C., Wooff, A., & Morrison, K. (2021). Locked Down, Locked Out?: Local Partnership Resilience in the Covid-19 Pandemic - A Report on Interim Findings. Edinburgh: Edinburgh Napier University

This report presents interim findings from a research project on local partnership working and resilience in the Covid-19 pandemic and associated lockdown measures. This grant is funded by the Economic and Social Research Council (ESRC) as part of UK... Read More about Locked Down, Locked Out?: Local Partnership Resilience in the Covid-19 Pandemic - A Report on Interim Findings.

Seasonal and Ontogenetic Variation in Depth Use by a Critically Endangered Benthic Elasmobranch and Its Implications for Spatial Management (2021)
Journal Article
Thorburn, J. A., Wright, P., Lavender, E., Dodd, J., Neat, F., Martin, J., Lynam, C., & James, M. A. (2021). Seasonal and Ontogenetic Variation in Depth Use by a Critically Endangered Benthic Elasmobranch and Its Implications for Spatial Management. Frontiers in Marine Science, 8, Article 656368. https://doi.org/10.3389/fmars.2021.656368

Seasonal and ontogenetic variation in depth use by benthic species are often concomitant with changes in their spatial distribution. This has implications for the efficacy of spatial conservation measures such as Marine Protected Areas (MPAs). The cr... Read More about Seasonal and Ontogenetic Variation in Depth Use by a Critically Endangered Benthic Elasmobranch and Its Implications for Spatial Management.

Staphylococcus aureus nasal colonization among dental health care workers in Northern Germany (StaphDent study) (2021)
Journal Article
Lerche, N., Holtfreter, S., Walther, B., Semmler, T., Al’Sholui, F., Dancer, S. J., Daeschlein, G., Hübner, N., Bröker, B. M., Papke, R., Kohlmann, T., Baguhl, R., Seifert, U., & Kramer, A. (2021). Staphylococcus aureus nasal colonization among dental health care workers in Northern Germany (StaphDent study). International Journal of Medical Microbiology, 311(6), Article 151524. https://doi.org/10.1016/j.ijmm.2021.151524

Methicillin-resistant Staphylococcus aureus (MRSA) can colonize dental patients and students, however, studies on the prevalence of MRSA and methicillin-susceptible S. aureus (MSSA) among dental health care workers (DHCW) including use of personal pr... Read More about Staphylococcus aureus nasal colonization among dental health care workers in Northern Germany (StaphDent study).

The Edinburgh Lifetime Musical Experience Questionnaire (ELMEQ): Responses and non-musical correlates in the Lothian Birth Cohort 1936 (2021)
Journal Article
Okely, J. A., Deary, I. J., & Overy, K. (2021). The Edinburgh Lifetime Musical Experience Questionnaire (ELMEQ): Responses and non-musical correlates in the Lothian Birth Cohort 1936. PLOS ONE, 16(7), Article e0254176. https://doi.org/10.1371/journal.pone.0254176

There is growing evidence of the potential effects of musical training on the human brain, as well as increasing interest in the potential contribution of musical experience to healthy ageing. Conducting research on these topics with older adults req... Read More about The Edinburgh Lifetime Musical Experience Questionnaire (ELMEQ): Responses and non-musical correlates in the Lothian Birth Cohort 1936.

Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated (2021)
Journal Article
Taylor, G. S., Shaw, A., Smith, K., Capper, T. E., Scragg, J. H., Cronin, M., Bashir, A., Flatt, A., Campbell, M. D., Stevenson, E. J., Shaw, J. A., Ross, M., & West, D. J. (2021). Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated. Scientific Reports, 11, Article 14502. https://doi.org/10.1038/s41598-021-93886-2

Background: Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (EPCs) is completely lacking in type 1 diabetes (T1D). Clarification, along... Read More about Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated.

What treatment and services are effective for people who are homeless and use drugs? A systematic ‘review of reviews’ (2021)
Journal Article
Miler, J. A., Carver, H., Masterton, W., Parkes, T., Maden, M., Jones, L., & Sumnall, H. (2021). What treatment and services are effective for people who are homeless and use drugs? A systematic ‘review of reviews’. PLOS ONE, 16(7), Article e0254729. https://doi.org/10.1371/journal.pone.0254729

Background People who experience homelessness and those vulnerably housed experience disproportionately high rates of drug use and associated harms, yet barriers to services and support are common. We undertook a systematic ‘review of reviews’ to in... Read More about What treatment and services are effective for people who are homeless and use drugs? A systematic ‘review of reviews’.

CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients (2021)
Journal Article
Muggeridge, D., Dodd, J., & Ross, M. D. (2021). CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients. Atherosclerosis, 333, 108-115. https://doi.org/10.1016/j.atherosclerosis.2021.07.004

Background and aims Circulating progenitor cells (CPCs) play an important role in vascular repair and can influence cardiovascular (CV) health and longevity. Exercise is known to modulate these cells via mobilization from the bone marrow. The primar... Read More about CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients.

Perceived load, fatigue and recovery responses during congested and non-congested micro-cycles in international football tournaments (2021)
Journal Article
Noor, D., McCall, A., Jones, M., Duncan, C., Ehrmann, F., Meyer, T., & Duffield, R. (2021). Perceived load, fatigue and recovery responses during congested and non-congested micro-cycles in international football tournaments. Journal of Science and Medicine in Sport, 24(12), 1278-1283. https://doi.org/10.1016/j.jsams.2021.07.001

Objectives To describe the perceived load, fatigue and recovery profiles during congested and non-congested schedules in international football tournaments. Design Retrospective single-cohort observational study. Methods Internal load (sessi... Read More about Perceived load, fatigue and recovery responses during congested and non-congested micro-cycles in international football tournaments.