Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells
(2023)
Journal Article
Mersal, K. I., Abdel-Maksoud, M. S., Ali, E. M., Ammar, U. M., Zaraei, S., Haque, M. M., Das, T., Hassan, N. F., Kim, E. E., Lee, J., Park, H., Lee, K. H., El-Gamal, M. I., Kim, H., Ibrahim, T. M., & Oh, C. (2023). Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells. European Journal of Medicinal Chemistry, 261, Article 115779. https://doi.org/10.1016/j.ejmech.2023.115779
A series of 36 pyrazol-4-yl pyridine derivatives (8a-i, 9a-i, 10a-i, and 11a-i) was designed, synthesized, and evaluated for its antiproliferative activity over NCI-60 cancer cell line panel and inhibitory effect against JNK isoforms (JNK1, JNK2, and... Read More about Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.