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All Outputs (161)

Modernizing UK health services:‘short-sharp-shock’reform, the NHS subsistence economy, and the spectre of health care famine (2005)
Journal Article
Charlton, B. G., & Andras, P. (2005). Modernizing UK health services:‘short-sharp-shock’reform, the NHS subsistence economy, and the spectre of health care famine. Journal of Evaluation in Clinical Practice, 11(2), 111-119. https://doi.org/10.1111/j.1365-2753.2005.00515.x

Modernization is the trend for societies to grow functionally more complex, efficient and productive. Modernization usually occurs by increased specialization of function (e.g. division of labour, such as the proliferation of specialists  in  medicin... Read More about Modernizing UK health services:‘short-sharp-shock’reform, the NHS subsistence economy, and the spectre of health care famine.

Medical research funding may have over-expanded and be due for collapse (2005)
Journal Article
Charlton, B., & Andras, P. (2005). Medical research funding may have over-expanded and be due for collapse. QJM: An International Journal of Medicine, 98(1), 53-55. https://doi.org/10.1093/qjmed/hci003

The continual and uninterrupted expansion of medical research funding is generally assumed to be a permanent feature of modern societies, but this expectation may turn out to be mistaken. Sciences tend to go through boom and bust phases. Twentieth ce... Read More about Medical research funding may have over-expanded and be due for collapse.

Management from the perspective of systems theory (2004)
Presentation / Conference Contribution
Andras, P., & Charlton, B. G. (2004, July). Management from the perspective of systems theory. Presented at Practising Philosophy of Management, Oxford

Usual management theories focus on phenomenological aspects of organisations and management. Abstract communication systems theory offers a different approach, which can be used to analyze social systems, uncover their internal logic and structure, a... Read More about Management from the perspective of systems theory.

Neural activity pattern systems (2004)
Journal Article
Andras, P. (2005). Neural activity pattern systems. Neurocomputing, 65, 531-536. https://doi.org/10.1016/j.neucom.2004.10.041

Understanding how neural systems work needs appropriate models. Here we propose a model that describes neural systems in terms of abstract communication systems. We indicate how to apply the proposed framework to the analysis of real neural systems.

Bacillus Subtilis protein interaction network analysis (2004)
Presentation / Conference Contribution
Idowu, O. C., Lynden, S. J., Young, M. P., & Andras, P. (2004, August). Bacillus Subtilis protein interaction network analysis. Presented at 2004 IEEE Computational Systems Bioinformatics Conference, Stanford, CA, USA

Identifying functionally important proteins that are essential to the survival of a bacterial cell is of considerable interest in the development of new antimicrobial agents. Recent studies have shown that functionally important components in protein... Read More about Bacillus Subtilis protein interaction network analysis.

e-Science Tools for the Analysis of Complex Systems (2004)
Presentation / Conference Contribution
Idowu, O., Lynden, S., & Andras, P. (2004, August). e-Science Tools for the Analysis of Complex Systems. Presented at UK e-Science All Hands Meeting 2004, Nottingham


Many real world complex systems (e.g., protein-protein interaction networks in living cells, the Internet) can be conceptualised as graphs of interacting components, where the components are the nodes and the interactions are the edges of the grap... Read More about e-Science Tools for the Analysis of Complex Systems.

Dealing with complex networks of process interactions: A security measure (2004)
Presentation / Conference Contribution
Periorellis, P., Idowu, O. C., Lynden, S. J., Young, M. P., & András, P. (2004, April). Dealing with complex networks of process interactions: A security measure. Presented at Ninth IEEE International Conference on Engineering of Complex Computer Systems, Florence, Italy

The majority of faults and consequent errors and failures in computer systems stem from the complexity of the system itself according to B. Schneier (2000). Yet complexity as a non-functional property is largely disregarded from initial development p... Read More about Dealing with complex networks of process interactions: A security measure.

Method and apparatus for identifying components of a network having high importance for network integrity (2004)
Patent
Young, M. P., Andras, P. E., & O'Neill, M. A. (2004). Method and apparatus for identifying components of a network having high importance for network integrity. WO2004040497A3

A computer system (2) is provided which is arranged to receive network data (1) identifying nodes and links between nodes. The computer system (2) processes the input network data (1) to utilise the network topology to identify nodes and links having... Read More about Method and apparatus for identifying components of a network having high importance for network integrity.

Protein interaction network topology analysis for drug target discovery (2004)
Presentation / Conference Contribution
Lynden, S., Idowu, O., Periorellis, P., Young, M., & Andras, P. (2004, May). Protein interaction network topology analysis for drug target discovery. Presented at Japan Human Proteomics 2004, Tokyo, Japan

The aim of our work is to accumulate protein interaction data and to develop computational techniques for analysing the topologies of protein interaction networks to reveal network vulnerabilities. We have developed a variety of network analysis algo... Read More about Protein interaction network topology analysis for drug target discovery.

Pattern languages: a new paradigm for neurocomputation (2004)
Journal Article
Andras, P. (2004). Pattern languages: a new paradigm for neurocomputation. Neurocomputing, 58-60, 223-228. https://doi.org/10.1016/j.neucom.2004.01.047

Existing neurocomputation models do not describe very faithfully biological neural systems. Here we offer a new look at neural activity data, by introducing the paradigm of pattern languages. Biological examples are presented to provide the biologica... Read More about Pattern languages: a new paradigm for neurocomputation.

A model for emergent complex order in small neural networks (2003)
Journal Article
Andras, P. (2003). A model for emergent complex order in small neural networks. Journal of Integrative Neuroscience, 2(1), 55-69. https://doi.org/10.1142/S0219635203000172

A new neural network model is introduced in this paper. The aim of the proposed Sierpinski neural networks is to provide a simple and biologically plausible neural network architecture that produces emergent complex spatio-temporal patterns through t... Read More about A model for emergent complex order in small neural networks.

Software Suite to Aid Protein Target Identification for Rational Drug Discovery (2003)
Presentation / Conference Contribution
Idowu, O., Lynden, S., Periorellis, P., Young, M., & Andras, P. (2003, September). Software Suite to Aid Protein Target Identification for Rational Drug Discovery. Presented at Cold Spring Harbour Laboratory and Wellcome Trust Conference on Pharmacogenomics

The process of rational drug discovery requires analysis of complex biological systems such as protein-protein interaction, metabolic pathways and gene interaction networks. Our aim is to develop a software suite for data retrieval and analysis that... Read More about Software Suite to Aid Protein Target Identification for Rational Drug Discovery.

A Model for Emergent Chaotic Order in Small Neural Networks (2003)
Journal Article
Andras, P. (2003). A Model for Emergent Chaotic Order in Small Neural Networks. Journal of Integrative Neuroscience, 2(1), 55-69. https://doi.org/10.1142/S0219635203000172

A new neural network model is introduced in this paper. The aim of the proposed Sierpinski neural networks is to provide a simple and biologically plausible neural network architecture that produces emergent complex spatio-temporal patterns through t... Read More about A Model for Emergent Chaotic Order in Small Neural Networks.

What is management and what do managers do? A systems theory account (2003)
Journal Article
Charlton, B. G., & Andras, P. (2003). What is management and what do managers do? A systems theory account. Philosophy of Management, 3, 3-15. https://doi.org/10.5840/pom2003332

Systems Theory analyses the world in terms of communications and divides the natural world into environment and systems. Systems are characterised by their high density of communications and tend to become more complex and efficient with time, usuall... Read More about What is management and what do managers do? A systems theory account.

Alternative sampling methods for estimating multivariate normal probabilities (2003)
Journal Article
Sándor, Z., & András, P. (2004). Alternative sampling methods for estimating multivariate normal probabilities. Journal of Econometrics, 120(2), 207-234. https://doi.org/10.1016/S0304-4076%2803%2900212-4

We study the performance of alternative sampling methods for estimating multivariate normal probabilities through the GHK simulator. The sampling methods are randomized versions of some quasi-Monte Carlo samples (Halton, Niederreiter, Niederreiter–Xi... Read More about Alternative sampling methods for estimating multivariate normal probabilities.

Understanding neural computation in terms of pattern languages (2003)
Presentation / Conference Contribution
András, P. (2003, July). Understanding neural computation in terms of pattern languages. Presented at International Joint Conference on Neural Networks, Portland, OR, USA

There is some experimental evidence that the neural information processing in some small neural systems with complex behaviour (e.g., olfactory bulb, crab stomatogastric ganglion) can be best described in terms of activity patterns. Recently the patt... Read More about Understanding neural computation in terms of pattern languages.