Bacillus Subtilis protein interaction network analysis

Idowu, Olusola C.; Lynden, Steven J.; Young, Malcolm P.; Andras, Peter

Abstract

Identifying functionally important proteins that are essential to the survival of a bacterial cell is of considerable interest in the development of new antimicrobial agents. Recent studies have shown that functionally important components in protein interaction networks may also be structurally important. We studied the protein interaction network of Bacillus subtilis to identify structurally essential proteins. Fifty-four percent of the structurally essential proteins identified by our methods were encoded by functionally essential genes.

Citation

Idowu, O. C., Lynden, S. J., Young, M. P., & Andras, P. (2004, August). Bacillus Subtilis protein interaction network analysis. Presented at 2004 IEEE Computational Systems Bioinformatics Conference, Stanford, CA, USA

• Presentation Conference Type: Conference Paper (published)
• Conference Name: 2004 IEEE Computational Systems Bioinformatics Conference
• Start Date: Aug 19, 2004
• Online Publication Date: Oct 8, 2004
• Publication Date: 2004
• Deposit Date: Nov 23, 2021
• Publisher: Institute of Electrical and Electronics Engineers
• Pages: 623-625
• Book Title: Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.
• ISBN: 0-7695-2194-0
• DOI: https://doi.org/10.1109/CSB.2004.1332520
• Keywords: Bacillus subtilis, protein interaction network analysis, bacterial cell survival, antimicrobial agents, structurally essential protein identification, functionally essential genes
• Public URL: http://researchrepository.napier.ac.uk/Output/2809179