All Outputs (55)

Accelerating the development of a psychological intervention to restore treatment decision-making capacity in patients with schizophrenia-spectrum disorder: a study protocol for a multi-site, assessor-blinded, pilot Umbrella trial (the DEC:IDES trial) (2023)
Journal Article
Hutton, P., Kelly, J., Taylor, C. D., Williams, B., Emsley, R., Alexander, C. H., Vikram, A., Saddington, D., McCann, A., Burke, J., Eliasson, E., Harper, S., Karatzias, T., Taylor, P. J., Watson, A., Dougall, N., Stavert, J., O’Rourke, S., Glasgow, A., Murphy, R., …Woodrow, A. (2023). Accelerating the development of a psychological intervention to restore treatment decision-making capacity in patients with schizophrenia-spectrum disorder: a study protocol for a multi-site, assessor-blinded, pilot Umbrella trial (the DEC:IDES trial). Pilot and Feasibility Studies, 9, Article 117. https://doi.org/10.1186/s40814-023-01323-0

Background:
A high proportion of patients diagnosed with schizophrenia-spectrum disorders will at some point in their lives be assessed as not having the capacity to make their own decisions about pharmacological treatment or inpatient care (‘capaci... Read More about Accelerating the development of a psychological intervention to restore treatment decision-making capacity in patients with schizophrenia-spectrum disorder: a study protocol for a multi-site, assessor-blinded, pilot Umbrella trial (the DEC:IDES trial).

Discerning the adverse effects of psychological therapy: consensus between experts by experience and therapists (2021)
Journal Article
McGlanaghy, E., Jackson, J., Morris, P., Prentice, W., Dougall, N., & Hutton, P. (2022). Discerning the adverse effects of psychological therapy: consensus between experts by experience and therapists. Clinical Psychology and Psychotherapy, 29(2), 579-589. https://doi.org/10.1002/cpp.2648

Measurement of adverse effects of psychological therapy is inconsistent due to ambiguity about the concept. The perspective of people undertaking psychological therapy (that is, experts by experience) has largely been overlooked. This study will inve... Read More about Discerning the adverse effects of psychological therapy: consensus between experts by experience and therapists.

A network meta-analysis of psychological interventions for schizophrenia and psychosis: impact on symptoms (2021)
Journal Article
Mc Glanaghy, E., Turner, D., Davis, G. A., Sharpe, H., Dougall, N., Morris, P., Prentice, W., & Hutton, P. (2021). A network meta-analysis of psychological interventions for schizophrenia and psychosis: impact on symptoms. Schizophrenia Research, 228, https://doi.org/10.1016/j.schres.2020.12.036

Background: Evidence for the effectiveness of psychological interventions for schizophrenia/psychosis is growing, however there is no consensus on the psychological intervention most likely to reduce symptoms.

Methods: A network meta-analysis was... Read More about A network meta-analysis of psychological interventions for schizophrenia and psychosis: impact on symptoms.

Psychological interventions for ICD-11 Complex PTSD symptoms: Systematic review and meta-analysis (2019)
Journal Article
Karatzias, T., Murphy, P., Cloitre, M., Bisson, J., Roberts, N., Shevlin, M., Hyland, P., Maercker, A., Ben-Ezra, M., Coventry, P., Mason-Roberts, S., Bradley, A., & Hutton, P. (2019). Psychological interventions for ICD-11 Complex PTSD symptoms: Systematic review and meta-analysis. Psychological Medicine, 49(11), 1761-1775. https://doi.org/10.1017/S0033291719000436

Background: The 11th revision to the WHO International Classification of Diseases (ICD-11) identified Complex Posttraumatic Stress Disorder (CPTSD) as a new condition. There is a pressing need to identify effective CPTSD interventions. Methods: We co... Read More about Psychological interventions for ICD-11 Complex PTSD symptoms: Systematic review and meta-analysis.

Cognitive behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT (2019)
Journal Article
Morrison, A. P., Pyle, M., Gumley, A., Schwannauer, M., Turkington, D., MacLennan, G., Norrie, J., Hudson, J., Bowe, S., French, P., Hutton, P., Byrne, R., Syrett, S., Dudley, R., McLeod, H. J., Griffiths, H., Barnes, T. R., Davies, L., Shields, G., Buck, D., …Kingdon, D. (2019). Cognitive behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT. Health Technology Assessment, 23(7), 1-144. https://doi.org/10.3310/hta23070

Background: Clozapine (clozaril, Mylan Products Ltd) is a first-choice treatment for people withschizophrenia who have a poor response to standard antipsychotic medication. However, a significant number of patients who trial clozapine have an inadequ... Read More about Cognitive behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT.

A feasibility study of a cross-diagnostic, CBT-based psychological intervention for acute mental health inpatients: Results, challenges, and methodological implications (2018)
Journal Article
Paterson, C., Karatzias, T., Harper, S., Dougall, N., Dickson, A., & Hutton, P. (2019). A feasibility study of a cross-diagnostic, CBT-based psychological intervention for acute mental health inpatients: Results, challenges, and methodological implications. British Journal of Clinical Psychology, 58(2), 211-230. https://doi.org/10.1111/bjc.12209

Objectives
Acute psychiatric inpatient wards are characterised by minimal provision of therapeutic activities and high readmission rates. Implementation of a comprehensive inpatient psychological intervention service has been recommended to overcome... Read More about A feasibility study of a cross-diagnostic, CBT-based psychological intervention for acute mental health inpatients: Results, challenges, and methodological implications.

Suicidal ideation in people with psychosis not taking antipsychotic medication: Do negative appraisals and negative metacognitive beliefs mediate the effect of symptoms? (2018)
Journal Article
Hutton, P., Di Rienzo, F., Turkington, D., Spencer, H., & Taylor, P. (2019). Suicidal ideation in people with psychosis not taking antipsychotic medication: Do negative appraisals and negative metacognitive beliefs mediate the effect of symptoms?. Schizophrenia Bulletin, 45(1), 37-47. https://doi.org/10.1093/schbul/sby153

Between 5 and 10 percent of people with psychosis will die by suicide, a rate which is 20 to 75 times higher than the general population. This risk is even greater in those not taking antipsychotic medication. We examined whether negative appraisals... Read More about Suicidal ideation in people with psychosis not taking antipsychotic medication: Do negative appraisals and negative metacognitive beliefs mediate the effect of symptoms?.

The paranoia as defence model of persecutory delusions: a systematic review and meta-analysis (2018)
Journal Article
Murphy, P., Bentall, R. P., Freeman, D., O'Rourke, S., & Hutton, P. (2018). The paranoia as defence model of persecutory delusions: a systematic review and meta-analysis. Lancet Psychiatry, 5(11), 913-929. https://doi.org/10.1016/S2215-0366%2818%2930339-0

Background
An influential psychological model of persecutory delusions proposed they are caused by a bias towards holding others responsible for negative events, which serves to prevent underlying low self-esteem from reaching awareness. An early (1... Read More about The paranoia as defence model of persecutory delusions: a systematic review and meta-analysis.

The effect of reducing the 'jumping to conclusions' bias on treatment decision-making capacity in psychosis: A randomised controlled trial with mediation analysis (2018)
Journal Article
Turner, D. T., MacBeth, A., Larkin, A., Moritz, S., Livingstone, K., Campbell, A., & Hutton, P. (2019). The effect of reducing the 'jumping to conclusions' bias on treatment decision-making capacity in psychosis: A randomised controlled trial with mediation analysis. Schizophrenia Bulletin, 45(4), 784-793. https://doi.org/10.1093/schbul/sby136

Background
Evidence-based psychological interventions to support treatment decision-making capacity (‘capacity’) in psychosis do not currently exist. This study sought to establish whether reducing the extent to which this group form conclusions bas... Read More about The effect of reducing the 'jumping to conclusions' bias on treatment decision-making capacity in psychosis: A randomised controlled trial with mediation analysis.

Decision-making ability in psychosis: a systematic review and meta-analysis of the magnitude, specificity and correlates of impaired performance on the Iowa and Cambridge Gambling Tasks (2018)
Journal Article
Woodrow, A., Sparks, S., Bobrovskaia, V., Paterson, C., Murphy, P., & Hutton, P. (2019). Decision-making ability in psychosis: a systematic review and meta-analysis of the magnitude, specificity and correlates of impaired performance on the Iowa and Cambridge Gambling Tasks. Psychological Medicine, 49(1), 32-48. https://doi.org/10.1017/S0033291718002660

To identify factors which may help or hinder decision-making ability in people with psychosis, we did a systematic review and meta-analysis of their performance on the Iowa and Cambridge Gambling Tasks. Analysis of 47 samples found they had moderatel... Read More about Decision-making ability in psychosis: a systematic review and meta-analysis of the magnitude, specificity and correlates of impaired performance on the Iowa and Cambridge Gambling Tasks.

A systematic review and meta-analysis of group treatments for adults with symptoms associated with complex post-traumatic stress disorder (2018)
Journal Article
Mahoney, A., Karatzias, T., & Hutton, P. (2018). A systematic review and meta-analysis of group treatments for adults with symptoms associated with complex post-traumatic stress disorder. Journal of Affective Disorders, https://doi.org/10.1016/j.jad.2018.09.059

Background: No previous meta-analyses have specifically investigated the effectiveness of psychological group therapy for symptoms associated with complex interpersonal trauma, including whether trauma memory processing (TMP) therapies are superior t... Read More about A systematic review and meta-analysis of group treatments for adults with symptoms associated with complex post-traumatic stress disorder.

Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome? (2018)
Journal Article
Spencer, H. M., McMenamin, M., Emsley, R., Turkington, D., Dunn, G., Morrison, A. P., Brabban, A., Hutton, P., & Dudley, R. (2018). Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?. Schizophrenia Research, 202, 385-386. https://doi.org/10.1016/j.schres.2018.07.016

This study investigated the effect of “dose” and the components of Cognitive Behavioral Therapy (CBT) on treatment effects. It is a secondary analysis of the ACTION (Assessment of Cognitive Therapy Instead of Neuroleptics) trial which investigated CB... Read More about Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?.

Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial (2018)
Journal Article
Morrison, A. P., Pyle, M., Gumley, A., Schwannauer, M., Turkington, D., MacLennan, G., Norrie, J., Hudson, J., Bowe, S. E., French, P., Byrne, R., Syrett, S., Dudley, R., McLeod, H. J., Griffiths, H., Barnes, T. R. E., Davies, L., Kingdon, D., Aydinlar, S., Courtley, J., …Tully, S. (2018). Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial. Lancet Psychiatry, 5(8), 633-643. https://doi.org/10.1016/s2215-0366%2818%2930184-6

Background
Although clozapine is the treatment of choice for treatment-refractory schizophrenia, 30–40% of patients have an insufficient response, and others are unable to tolerate it. Evidence for any augmentation strategies is scarce. We aimed to... Read More about Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial.

Cognitive Analytic Therapy for Psychosis: A Case Series (2018)
Journal Article
Taylor, P. J., Taylor, P., Perry, A., Hutton, P., Tan, R., Fisher, N., Focone, C., Griffiths, D., & Seddon, C. (2019). Cognitive Analytic Therapy for Psychosis: A Case Series. Psychology and Psychotherapy: Theory, Research and Practice, 92(3), 359-378. https://doi.org/10.1111/papt.12183

Objectives: Cognitive Analytic Therapy (CAT) is an effective psychological intervention for several different mental health conditions. However, whether it is acceptable, safe and beneficial for people with psychosis remains unclear, as is the feasib... Read More about Cognitive Analytic Therapy for Psychosis: A Case Series.

Psychological therapy for inpatients receiving acute mental health care: A systematic review and meta-analysis of controlled trials (2018)
Journal Article
Paterson, C., Karatzias, T., Dickson, A., Harper, S., Dougall, N., & Hutton, P. (2018). Psychological therapy for inpatients receiving acute mental health care: A systematic review and meta-analysis of controlled trials. British Journal of Clinical Psychology, 57(4), 453-472. https://doi.org/10.1111/bjc.12182

Objectives
The effectiveness of psychological therapies for those receiving acute adult mental health inpatient care remains unclear, partly because of the difficulty in conducting randomised controlled trials (RCTs) in this setting. The aim of this... Read More about Psychological therapy for inpatients receiving acute mental health care: A systematic review and meta-analysis of controlled trials.

Should people with psychosis be supported in choosing cognitive therapy as an alternative to antipsychotic medication: A commentary on a commentary (2018)
Journal Article
Hutton, P. (2018). Should people with psychosis be supported in choosing cognitive therapy as an alternative to antipsychotic medication: A commentary on a commentary. Schizophrenia Research, https://doi.org/10.1016/j.schres.2018.04.002

Item is a commentary. No abstract available.

Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis (2017)
Journal Article
Larkin, A., & Hutton, P. (2017). Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis. British Journal of Psychiatry, 211(4), 205-215. https://doi.org/10.1192/bjp.bp.116.193458

Background: The evidence on factors that may influence treatment decisional capacity (‘capacity) in psychosis has yet to be comprehensively synthesised, which limits the development of effective strategies to improve or support it.
Aims: To determin... Read More about Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis.

Practitioner Review: Therapist variability, patient-reported therapeutic alliance, and clinical outcomes in adolescents undergoing mental health treatment - a systematic review and meta-analysis (2017)
Journal Article
Murphy, R., & Hutton, P. (2017). Practitioner Review: Therapist variability, patient-reported therapeutic alliance, and clinical outcomes in adolescents undergoing mental health treatment - a systematic review and meta-analysis. Journal of Child Psychology and Psychiatry, 59(1), 5-19. https://doi.org/10.1111/jcpp.12767

Background: Previous meta-analyses have only found small correlations (r=0.10 to r=0.19) between therapeutic alliance and clinical outcomes in samples of adolescents receiving psychological therapy. Although study-level variables have been found to m... Read More about Practitioner Review: Therapist variability, patient-reported therapeutic alliance, and clinical outcomes in adolescents undergoing mental health treatment - a systematic review and meta-analysis.

Loneliness in Psychosis: A Meta-analytical Review (2017)
Journal Article
Michalska da Rocha, B., Vasilopoulou, E., Rhodes, S., & Hutton, P. (2018). Loneliness in Psychosis: A Meta-analytical Review. Schizophrenia Bulletin, 44(1), 114-125. https://doi.org/10.1093/schbul/sbx036

Loneliness may be related to psychotic symptoms but a comprehensive synthesis of the literature in this area is lacking. The aim of the current study is to determine the magnitude and reliability of the loneliness-psychosis relationship in people dia... Read More about Loneliness in Psychosis: A Meta-analytical Review.

The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis (2017)
Journal Article
Bordon, N., O'Rourke, S., & Hutton, P. (2017). The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis. Schizophrenia Research, 188, 3-12. https://doi.org/10.1016/j.schres.2017.01.014

Background
People diagnosed with schizophrenia have significant difficulty accurately recognising emotions expressed by others. This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psych... Read More about The feasibility and clinical benefits of improving facial affect recognition impairments in schizophrenia: Systematic review and meta-analysis.