All Outputs (2)

Design of new anticancer drugs by selectable intracellular organelle targeting: make for the mitochondria or turn left for the lysosome? (2024)
Presentation / Conference Contribution
Mincher, D., Kamel, M., Mohammed, O., MacCallum, J., & Turnbull, A. (2024, June). Design of new anticancer drugs by selectable intracellular organelle targeting: make for the mitochondria or turn left for the lysosome?. Presented at EACR 2024: Innovative Cancer Science, Rotterdam, Netherlands

Introduction Defining structural features that can control and pinpoint the delivery of drugs to specific sub-cellular organelles ofcancer cells offers the prospect of designing more potentand selective drugs that negate drug resistance, with less d... Read More about Design of new anticancer drugs by selectable intracellular organelle targeting: make for the mitochondria or turn left for the lysosome?.

Design, synthesis, and cytotoxicity of bifunctional anticancer agents targeted to mitochondria (2023)
Thesis
Kamel, M. A. Design, synthesis, and cytotoxicity of bifunctional anticancer agents targeted to mitochondria. (Thesis). Edinburgh Napier University

One of the major challenges of cancer chemotherapy is multidrug resistance (MDR) leading to failure and drug withdrawal. A major factor in drug resistance is the overexpression of transmembrane P-gp protein efflux pumps in cancer cell membranes that... Read More about Design, synthesis, and cytotoxicity of bifunctional anticancer agents targeted to mitochondria.