Skip to main content

Research Repository

Advanced Search

All Outputs (71)

Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS) (2025)
Presentation / Conference Contribution
Wang, Y., McCredie, R., Rae, M., Cahill, A., Duncan, C., & Siemienowicz, K. (2025, May). Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS). Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Prenatally androgenised female sheep are a clinically realistic model of PCOS. In adolescence (11 months of age) there is reduced subcutaneous adipogenesis and in adulthood (30 months of age) there is increased subcutaneous adipose tissue (SAT) dysfu... Read More about Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS).

Excess adrenal androgen secretion is a consequence of in utero androgen excess in an ovine model of PCOS (2025)
Presentation / Conference Contribution
Rae, M., Ramaswamy, S., Siemienowicz, K., McNeilly, A., Howie, F., Wilson, K., Hogg, K., & Duncan, W. C. (2025, May). Excess adrenal androgen secretion is a consequence of in utero androgen excess in an ovine model of PCOS. Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Evidence for bone marrow adipose tissue dysfunction in polycystic ovary syndrome (PCOS) (2025)
Presentation / Conference Contribution
McCredie, R., Levate, G., Wang, Y., Rae, M., Duncan, C., & Siemienowicz, K. (2025, May). Evidence for bone marrow adipose tissue dysfunction in polycystic ovary syndrome (PCOS). Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

The effect of intranasal insulin on post prandial thermogenesis in obese women with and without polycystic ovary syndrome (2025)
Presentation / Conference Contribution
Duncan, C., Wang, Y., McCredie, R., Franks, S., Fowler, P., Stimson, R., Rae, M., & Siemienowicz, K. (2025, May). The effect of intranasal insulin on post prandial thermogenesis in obese women with and without polycystic ovary syndrome. Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS). (2024)
Journal Article
Levate, G., Wang, Y., McCredie, R., Fenwick, M., Rae, M. T., Duncan, W. C., & Siemienowicz, K. J. (2025). Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, 595, Article 112416. https://doi.org/10.1016/j.mce.2024.112416

Adipose tissue dysfunction is one of the features of Polycystic Ovary Syndrome (PCOS) with dysregulated adipogenesis, altered functional pathways and increased inflammation. It is increasingly clear that there are also male correlates of the hormonal... Read More about Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS)..

Pregnancy length and health in giant pandas: what can metabolic and urinary endocrine markers unveil? (2023)
Journal Article
Wauters, J., Wilson, K. S., Cools, T., Vancsok, C., Bouts, T., Mulot, B., Leclerc, A., Haapakoski, M., Kok, J., Kühne, R., Ochs, A., Duncan, W. C., Girling, S. J., Hildebrandt, T. B., Zhou, Q., Li, R., Zhou, Y., Cai, K., Liu, Y., Hou, R., …Li, D. (2023). Pregnancy length and health in giant pandas: what can metabolic and urinary endocrine markers unveil?. Theriogenology Wild, 3, Article 100063. https://doi.org/10.1016/j.therwi.2023.100063

Mature female giant pandas usually ovulate once a year. This is followed by an obligatory luteal phase, consisting of a long-lasting corpus luteum dormancy phase (CLD; primary increase in progestogens) and a much shorter active luteal phase (AL; seco... Read More about Pregnancy length and health in giant pandas: what can metabolic and urinary endocrine markers unveil?.

Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation (2023)
Journal Article
Duncan, W. C., Nicol, L. M., O’Hare, R., Witherington, J., Miranda, J. A., Campbell, B. K., Thomas, J. L., & Rae, M. T. (2023). Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation. Frontiers in Endocrinology, 14, Article 1285269. https://doi.org/10.3389/fendo.2023.1285269

Introduction: Polycystic ovary syndrome (PCOS) seems to be associated with increased ovarian sympathetic nerve activity and in rodent models of PCOS reducing the sympathetic drive to the ovary, through denervation or neuromodulation, improves ovulati... Read More about Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation.

Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males” (2022)
Journal Article
Siemienowicz, K. J., Filis, P., Thomas, J., Fowler, P. A., Duncan, W. C., & Rae, M. T. (2022). Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”. Biomedicines, 10(6), Article 1291. https://doi.org/10.3390/biomedicines10061291

First-degree male relatives of polycystic ovary syndrome (PCOS) sufferers can develop metabolic abnormalities evidenced by elevated circulating cholesterol and triglycerides, suggestive of a male PCOS equivalent. Similarly, male sheep overexposed to... Read More about Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”.

Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment (2022)
Presentation / Conference Contribution
Ross, B. L., Malone, E. M., Rae, M. T., Bouwmeester, H., van der Zande, M., & Hutchison, G. R. (2022, March). Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, California

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells (2021)
Journal Article
Brown, M., Rae, M., & Wheelhouse, N. (2021). Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells. Reproduction and Fertility, 2(1), 9-11. https://doi.org/10.1530/RAF-20-0069

Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause reproductive complications including problems in conceiving a pregnancy th... Read More about Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells.

Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome (2021)
Journal Article
Siemienowicz, K. J., Furmanska, K., Filis, P., Talia, C., Thomas, J., Fowler, P. A., Rae, M. T., & Colin Duncan, W. (2021). Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Molecular and Cellular Endocrinology, 525, Article 111196. https://doi.org/10.1016/j.mce.2021.111196

Polycystic ovary syndrome (PCOS), affecting over 10% of women, is associated with insulin resistance, obesity, dyslipidaemia, fatty liver and adipose tissue dysfunction. Its pathogenesis is poorly understood and consequently treatment remains subopti... Read More about Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome.

Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses (2020)
Journal Article
Siemienowicz, K. J., Wang, Y., Marečková, M., Nio-Kobayashi, J., Fowler, P. A., Rae, M. T., & Duncan, W. C. (2020). Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-78976-x

Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in... Read More about Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses.

Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS) (2020)
Journal Article
Siemienowicz, K. J., Coukan, F., Franks, S., Rae, M. T., & Colin Duncan, W. (2021). Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, 519, Article 111042. https://doi.org/10.1016/j.mce.2020.111042

Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and increased adiposity are key factors contributing to metabolic dysfunction in PCOS. We hypothesised that aberrant adipogenesis duri... Read More about Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS).

Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS) (2020)
Journal Article
Siemienowicz, K., Rae, M. T., Howells, F., Anderson, C., Nicol, L. M., Franks, S., & Duncan, W. C. (2020). Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS). iScience, 23(6), Article 101164. https://doi.org/10.1016/j.isci.2020.101164

Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energy expenditure. We used a clinically-realistic preclinical model to investig... Read More about Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS).

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life (2019)
Presentation / Conference Contribution
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., Fowler, P., Duncan, C., & Rae, M. (2019, May). Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Presented at 21st European Congress of Endocrinology, Lyon, France

Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), and hyperinsulinaemia. As altered intrauterine endocrine environments can ‘... Read More about Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life.

Fetal androgen exposure is a determinant of adult male metabolic health (2019)
Journal Article
Siemienowicz, K. J., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., Howie, F., Fowler, P. A., Duncan, W. C., & Rae, M. T. (2019). Fetal androgen exposure is a determinant of adult male metabolic health. Scientific Reports, 9, Article 20195 (2019). https://doi.org/10.1038/s41598-019-56790-4

Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypothesised that poor adult male health was partially attributable to aberrant... Read More about Fetal androgen exposure is a determinant of adult male metabolic health.

Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca) (2019)
Journal Article
Wilson, K. S., Wauters, J., Valentine, I., McNeilly, A., Girling, S., Li, R., Li, D., Zhang, H., Rae, M. T., Howie, F., Andrew, R., & Duncan, W. C. (2019). Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca). Scientific Reports, 9(1), Article 12772. https://doi.org/10.1038/s41598-019-49288-6

Female giant pandas show complex reproductive traits, being seasonally monoestrus, displaying a variable length embryonic diapause and exhibiting pseudopregnancy. Currently, there is no confirmatory non-invasive biomarker of blastocyst implantation o... Read More about Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca).

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring (2018)
Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., Howie, A. F., Rae, M. T., Van Soom, A., Li, R., Li, D., Zhang, H., & Vanhaecke, L. (2018). Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), Article e0201420. https://doi.org/10.1371/journal.pone.0201420

Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results requires normalisation due to an animal’s changing hydration. Correction of urinar... Read More about Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring.

Physical Activity Index influence on all-cause mortality and vascular health measures: Findings from the Framingham Heart Study. European Journal of Sport Sciences (2018)
Presentation / Conference Contribution
Muggeridge, D., Rae, M., Florida-James, G., & Ross, M. (2018, July). Physical Activity Index influence on all-cause mortality and vascular health measures: Findings from the Framingham Heart Study. European Journal of Sport Sciences. Presented at 23rd Annual Congress of the European College of Sport Science, Dublin, Ireland