All Outputs (4)

Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure (2022)
Journal Article
Di Cristo, L., Janer, G., Dekkers, S., Boyles, M., Giusti, A., Keller, J. G., Wohlleben, W., Braakhuis, H., Ma-Hock, L., Oomen, A. G., Haase, A., Stone, V., Murphy, F., Johnston, H. J., & Sabella, S. (2022). Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure. Nanotoxicology, 16(3), 310-332. https://doi.org/10.1080/17435390.2022.2085207

Exposure to different nanoforms (NFs) via the dermal route is expected in occupational and consumer settings and thus it is important to assess their dermal toxicity and the contribution of dermal exposure to systemic bioavailability. We have formula... Read More about Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure.

Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays (2022)
Journal Article
Ag Seleci, D., Tsiliki, G., Werle, K., Elam, D. A., Okpowe, O., Seidel, K., Bi, X., Westerhoff, P., Innes, E., Boyles, M., Miller, M., Giusti, A., Murphy, F., Haase, A., Stone, V., & Wohlleben, W. (2022). Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays. NanoImpact, 26, Article 100390. https://doi.org/10.1016/j.impact.2022.100390

Grouping of substances is a method used to streamline hazard and risk assessment. Assessment of similarity provides the scientific evidence needed for formation of groups. This work reports on justification of grouping of nanoforms (NFs) via similari... Read More about Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays.

Bayesian based similarity assessment of nanomaterials to inform grouping (2022)
Journal Article
Tsiliki, G., Ag Seleci, D., Zabeo, A., Basei, G., Hristozov, D., Jeliazkova, N., Boyles, M., Murphy, F., Peijnenburg, W., Wohlleben, W., & Stone, V. (2022). Bayesian based similarity assessment of nanomaterials to inform grouping. NanoImpact, 25, Article 100389. https://doi.org/10.1016/j.impact.2022.100389

Nanoforms can be manufactured in plenty of variants by differing their physicochemical properties and toxicokinetic behaviour which can affect their hazard potential. To avoid testing of each single nanomaterial and nanoform variation and subsequentl... Read More about Bayesian based similarity assessment of nanomaterials to inform grouping.

Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials (2022)
Journal Article
Boyles, M., Murphy, F., Mueller, W., Wohlleben, W., Jacobsen, N. R., Braakhuis, H., Giusti, A., & Stone, V. (2022). Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials. Toxicology Mechanisms and Methods, 32(6), 439-452. https://doi.org/10.1080/15376516.2022.2029656

Improved strategies are required for testing nanomaterials (NMs) to make hazard and risk assessment more efficient and sustainable. Including reduced reliance on animal models, without decreasing the level of human health protection. Acellular detect... Read More about Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials.