All Outputs (3)

Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation (2019)
Journal Article
Hellyer, T. P., McAuley, D. F., Walsh, T. S., Anderson, N., Conway Morris, A., Singh, S., Dark, P., Roy, A. I., Perkins, G. D., McMullan, R., Emerson, L. M., Blackwood, B., Wright, S. E., Kefala, K., O'Kane, C. M., Baudouin, S. V., Paterson, R. L., Rostron, A. J., Agus, A., Bannard-Smith, J., …Simpson, A. J. (2020). Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation. Lancet Respiratory Medicine, 8(2), 182-191. https://doi.org/10.1016/S2213-2600%2819%2930367-4

Background
Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar lavage f... Read More about Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation.

A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT (2019)
Journal Article
Mouncey, P. R., Wade, D., Richards-Belle, A., Sadique, Z., Wulff, J., Grieve, R., Emerson, L. M., Brewin, C. R., Harvey, S., Howell, D., Hudson, N., Khan, I., Mythen, M., Smyth, D., Weinman, J., Welch, J., Harrison, D. A., & Rowan, K. M. (2019). A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT. Health Services and Delivery Research, 7(30), 1-174. https://doi.org/10.3310/hsdr07300

Background
High numbers of patients experience severe acute stress in critical care units. Acute stress has been linked to post-critical care psychological morbidity, including post-traumatic stress disorder (PTSD). Previously, a preventive, complex... Read More about A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT.

Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial (2019)
Journal Article
Wade, D. M., Mouncey, P. R., Richards-Belle, A., Wulff, J., Harrison, D. A., Sadique, M. Z., Grieve, R. D., Emerson, L. M., Mason, A. J., Aaronovitch, D., Als, N., Brewin, C. R., Harvey, S. E., Howell, D. C. J., Hudson, N., Mythen, M. G., Smyth, D., Weinman, J., Welch, J., Whitman, C., …for the POPPI Trial Investigators. (2019). Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial. Journal of the American Medical Association, 321(7), 665-675. https://doi.org/10.1001/jama.2019.0073

A meta-analysis of outcomes during the 6 months after intensive care unit (ICU) discharge indicate a prevalence for clinically important posttraumatic stress disorder (PTSD) symptoms of 25%.To determine whether a nurse-led preventive, complex psychol... Read More about Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial.