Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial

Aitken, Leanne M; Emerson, Lydia M; Kydonaki, Kalliopi; Blackwood, Bronagh; Creagh-Brown, Benedict; Lone, Nazir I; McKenzie, Cathrine A; Reade, Michael C; Weir, Christopher J; Wise, Matt P; Walsh, Timothy S

doi:10.1136/bmjopen-2023-081637

All Outputs (3)

Short duration antibiotic therapy for critically ill patients with sepsis (SHORTER trial): a mixed-methods process evaluation of a randomised controlled trial. (2024)
Presentation / Conference Contribution
Wojcik, G., Emerson, L., & Hellyer, T. (2024, September). Short duration antibiotic therapy for critically ill patients with sepsis (SHORTER trial): a mixed-methods process evaluation of a randomised controlled trial. Presented at International Clinical Trials Methodology Conference, Edinburgh, UK

Introduction

Sepsis is a life-threatening organ dysfunction resulting from infection, and a leading global cause of death.1 Timely antibiotic administration is crucial, with guidelines recommending initiation within one hour of recognising severe... Read More about Short duration antibiotic therapy for critically ill patients with sepsis (SHORTER trial): a mixed-methods process evaluation of a randomised controlled trial..

Process Evaluation in Critical Care Trials: A Qualitative Evidence Synthesis Protocol (2024)
Preprint / Working Paper
Wojcik, G., Emerson, L., Blackwood, B., Aitken, L., & Smith, D. (online). Process Evaluation in Critical Care Trials: A Qualitative Evidence Synthesis Protocol

Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial (2024)
Journal Article
Aitken, L. M., Emerson, L. M., Kydonaki, K., Blackwood, B., Creagh-Brown, B., Lone, N. I., McKenzie, C. A., Reade, M. C., Weir, C. J., Wise, M. P., & Walsh, T. S. (2024). Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial. BMJ Open, 14(4), Article e081637. https://doi.org/10.1136/bmjopen-2023-081637

Introduction: An association between deep sedation and adverse short-term outcomes has been demonstrated although this evidence has been inconsistent. The A2B (alpha-2 agonists for sedation in critical care) sedation trial is designed to determine wh... Read More about Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial.