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Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages (1996)
Journal Article
Proudfoot, L., Nikolaev, A. V., Feng, G., Wei, X., Ferguson, M. A. J., Brimacombe, J. S., & Liew, F. Y. (1996). Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine

Lipophosphoglycan (LPG) glycoconjugates from promastigotes of Leishmania were not able to induce the expression of the cytokine-inducible nitric oxide synthase (iNOS) by the murine macrophage cell line, J774. However, they synergize with interferon y... Read More about Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages.

Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major (1995)
Journal Article
Proudfoot, L., Schneider, P., Ferguson, M. A. J., & McConville, M. J. (1995). Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major. The biochemical journal, 308(1), 45-55. https://doi.org/10.1042/bj3080045

The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a glycosylphosphatidylinositol glycolipid anchor. This parasite also synthesizes a complex family of abundant low-molecular-... Read More about Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major.

Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages (1995)
Journal Article
Proudfoot, L., O'Donnell, C. A., & Liew, F. Y. (1995). Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages. European Journal of Immunology, 25(3), 745-750. https://doi.org/

Murine macrophages express high levels of inducible nitric oxide (NO) synthase and produce large amounts of nitric oxide when activated with interferon-gamma and lipopolysaccharide in vitro. Nitric oxide is a mediator of a variety of biological funct... Read More about Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages.

External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment (1993)
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., & Kennedy, M. W. (1993). External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment. Parasitology, 107(05), 559. https://doi.org/

Previous work has shown that the surface of infective larvae of parasitic nematodes will not bind the fluorescent lipid analogue 5-N(octadecanoyl)aminofluorescein (AF18) until after exposure of the parasite to mammalian tissue-culture conditions. In... Read More about External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment.

Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms (1993)
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1993). Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms. Parasitology, 107(01), 107. doi:10.1017/s00311820000794

All mammalian-parasitic stages of a range of nematode species investigated (Brugia pahangi, Acanthocheilonema viteae, Strongyloides ratti, Nippostrongylus brasiliensis, Trichinella spiralis and Ostertagia ostertagi) labelled in a surface-restricted m... Read More about Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms.

The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment (1990)
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1990). The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment. Acta tropica, 47(5-6), 323-330. https://doi.org/10.1016/0001-706x%2890%2990033-v

The biophysical properties of the surface lipid of a range of nematode species and their developmental stages were examined, using fluorescent lipid probes and fluorescence recovery after photobleaching (FRAP). These methods can be applied to living,... Read More about The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment.