All Outputs (15)

BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1. (2016)
Journal Article
Oughtred, R., Chatr-aryamontri, A., Breitkreutz, B., Chang, C. S., Rust, J. M., Theesfeld, C. L., …Tyers, M. (2016). BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1. Cold Spring Harbor protocols, 2016(1), pdb.top080754. https://doi.org/10.1101/pdb.top080754

The Biological General Repository for Interaction Datasets (BioGRID) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evi... Read More about BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1..

Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions (2016)
Journal Article
Oughtred, R., Chatr-aryamontri, A., Breitkreutz, B., Chang, C. S., Rust, J. M., Theesfeld, C. L., …Tyers, M. (2016). Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions. Cold Spring Harbor protocols, 2016(1), pdb.prot088880. https://doi.org/10.1101/pdb.prot088880

The BioGRID database is an extensive repository of curated genetic and protein interactions for the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and the yeast Candida albicans SC5314, as well as for several oth... Read More about Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions.

The BioGRID interaction database: 2015 update (2014)
Journal Article
Chatr-aryamontri, A., Breitkreutz, B., Oughtred, R., Boucher, L., Heinicke, S., Chen, D., …Tyers, M. (2015). The BioGRID interaction database: 2015 update. Nucleic Acids Research, 43(D1), D470-D478. https://doi.org/10.1093/nar/gku1204

The Biological General Repository for Interaction Datasets (BioGRID: http://thebiogrid.org) is an open access database that houses genetic and protein interactions curated from the primary biomedical literature for all major model organism species an... Read More about The BioGRID interaction database: 2015 update.

Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells (2014)
Journal Article
Lipert, B., Wegrzyn, P., Sell, H., Eckel, J., Winiarski, M., Budzynski, A., …Jura, J. (2014). Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells. BBA - Molecular Cell Research, 1843(4), 780-788. https://doi.org/10.1016/j.bbamcr.2014.01.001

Monocyte chemoattractant protein-induced protein 1 (MCPIP1) encoded by the ZC3H12a gene (also known as Regnase-1) is involved in the regulation of degradation of mRNA of inflammatory modulators and for processing of pre-miRNA. These functions depend... Read More about Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells.

The BioGRID interaction database: 2013 update (2012)
Journal Article
Chatr-aryamontri, A., Breitkreutz, B., Heinicke, S., Boucher, L., Winter, A., Stark, C., …Tyers, M. (2013). The BioGRID interaction database: 2013 update. Nucleic Acids Research, 41(D1), D816-D823. https://doi.org/10.1093/nar/gks1158

The Biological General Repository for Interaction Datasets (BioGRID: http//thebiogrid.org) is an open access archive of genetic and protein interactions that are curated from the primary biomedical literature for all major model organism species. As... Read More about The BioGRID interaction database: 2013 update.

Integrins and extracellular matrix in mechanotransduction (2011)
Journal Article
Ramage, L. (2011). Integrins and extracellular matrix in mechanotransduction. Cell Health and Cytoskeleton, 2012(4), 1-9. https://doi.org/10.2147/chc.s21829

Integrins are a family of cell surface receptors which mediate cell–matrix and cell–cell adhesions. Among other functions they provide an important mechanical link between the cells external and intracellular environments while the adhesions that the... Read More about Integrins and extracellular matrix in mechanotransduction.

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading (2009)
Journal Article
Ramage, L., Nuki, G., & Salter, D. M. (2009). Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading. Scandinavian Journal of Medicine and Science in Sports, 19(4), 457-469. https://doi.org/10.1111/j.1600-0838.2009.00912.x

Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes and induces the synthesis of molecules to maintain the integrity of the cartilage. Mechanical signals modulate biochemical activity and changes in cell behav... Read More about Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading.

NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins (2008)
Journal Article
Ramage, L., Hardingham, G., & Salter, D. (2008). NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins. Osteoarthritis and Cartilage, 16(S4), S82. https://doi.org/10.1016/s1063-4584%2808%2960207-1

Purpose: Osteoarthritis (OA) is associated with abnormal loading of articular joints. In normal joints physiological loading maintains structure and function of cartilage and chondrocytes within. This is mediated by a process known as mechanotransduc... Read More about NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins.

NMDA receptor expression and activity in osteoarthritic human articular chondrocytes (2008)
Journal Article
Ramage, L., Martel, M., Hardingham, G. E., & Salter, D. M. (2008). NMDA receptor expression and activity in osteoarthritic human articular chondrocytes. Osteoarthritis and Cartilage, 16(12), 1576-1584. https://doi.org/10.1016/j.joca.2008.04.023

Objective: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and have roles in regulation of chondrocyte function. This study looks at expression and activity of the ionotropic glutamate NMDA... Read More about NMDA receptor expression and activity in osteoarthritic human articular chondrocytes.

P214 NMDA receptor signalling in human osteoarthritic chondrocytes. (2007)
Journal Article
Ramage, L., Hardingham, G., & Salter, D. (2007). P214 NMDA receptor signalling in human osteoarthritic chondrocytes. Osteoarthritis and Cartilage, 15, B142. https://doi.org/10.1016/s1063-4584%2807%2961569-6

Purpose: Human OA chondrocytes are known to express several subunits of the NMDA receptor (NMDAR), a neuronal signalling molecule. This study analyses downstream activation events and interactions of NMDAR with molecules known to be involved in chond... Read More about P214 NMDA receptor signalling in human osteoarthritic chondrocytes..

P186 Expression of functional NMDA receptors in human OA chondrocytes (2007)
Journal Article
Ramage, L., Martel, M., Hardingham, G., & Salter, D. (2007). P186 Expression of functional NMDA receptors in human OA chondrocytes. Osteoarthritis and Cartilage, 14(Supp. B), S108. https://doi.org/10.1016/s1063-4584%2807%2960638-4

Purpose: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and are being shown to have roles in regulation of chondrocyte function. This study looks at the expression and function of the metab... Read More about P186 Expression of functional NMDA receptors in human OA chondrocytes.

Induction of apoptosis with tobacco smoke and related products in A549 lung epithelial cells in vitro (2006)
Journal Article
Ramage, L., Jones, A. C., & Whelan, C. J. (2006). Induction of apoptosis with tobacco smoke and related products in A549 lung epithelial cells in vitro. Journal of Inflammation, 3(1), 3. https://doi.org/10.1186/1476-9255-3-3

Background This study has investigated the ability of tobacco smoke, and ingredients of tobacco smoke, to induce apoptosis in the airway epithelial cell line A549. Method A549 cells were treated with 80 μg/ml Tobacco smoke condensate (TSC), 10 mM... Read More about Induction of apoptosis with tobacco smoke and related products in A549 lung epithelial cells in vitro.

Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549) (2004)
Journal Article
Ramage, L., Jones, A., & Whelan, C. (2004). Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549). Inflammation Research, 53(S3), S207-S230. https://doi.org/10.1007/bf03353882

Cigarette smoke is known to be a complex mixture of >4000 constituents dispersed between the volatile and non-volatile phase, and inhaled exposure causes lung inflammation and cell injury. Here we investigate the effects of some of components of ciga... Read More about Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549).

Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles (2004)
Journal Article
Ramage, L., Proudfoot, L., & Guy, K. (2004). Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles. Inhalation Toxicology, 16(9), 607-613. https://doi.org/10.1080/08958370490464599

C-reactive protein (CRP) is the prototypic human acute-phase protein and is found at increased levels in the blood during episodes of inflammation. CRP was generally thought to be produced only by hepatocytes; however, several studies have shown extr... Read More about Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles.

Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure (2004)
Journal Article
Ramage, L., & Guy, K. (2004). Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure. Inhalation Toxicology, 16(6-7), 447-452. https://doi.org/10.1080/08958370490439614

Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this study we have investigated the effects of environmental air pollution partic... Read More about Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure.