Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers

Phillips, H.A.; MacCallum, J.; Burns, D.; Cho-Chung, Y.S.; Miller, W.R.

doi:10.1016/s0960-9776(98)90024-8

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Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers (1998)
Journal Article
Phillips, H., MacCallum, J., Burns, D., Cho-Chung, Y., & Miller, W. (1998). Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers. Breast, 7(3), 139-142. https://do

There is evidence that the regulatory subunits (R) of cyclic AMP-dependent protein kinase A (PKA) are important in the biology of breast cancer and that mutations of both RIα and RIIβ, alter cellular behaviour. Consequently, a PCR-SSCP assay was esta... Read More about Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers.