All Outputs (2)

Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria (2024)
Journal Article
Surendran, A., Turnbull, A., Flockhart, A., Findlay-Greene, F., Nowosielska, M., Morrison, D., Mincher, D. J., & Donnellan, S. (online). Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria. All Life, https://doi.org/10.1080/26895293.2024.2379309

We hypothesise that antimicrobial resistance (AMR) cannot be overcome by simply ‘drugging’ single biological targets, therefore, our focus is developing broad-spectrum therapeutics. Herein we present the synthesis of two novel spacer-linked, anthraqu... Read More about Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria.

Design of new anticancer drugs by selectable intracellular organelle targeting: make for the mitochondria or turn left for the lysosome? (2024)
Presentation / Conference Contribution
Mincher, D., Kamel, M., Mohammed, O., MacCallum, J., & Turnbull, A. (2024, June). Design of new anticancer drugs by selectable intracellular organelle targeting: make for the mitochondria or turn left for the lysosome?. Presented at EACR 2024: Innovative Cancer Science, Rotterdam, Netherlands

Introduction Defining structural features that can control and pinpoint the delivery of drugs to specific sub-cellular organelles ofcancer cells offers the prospect of designing more potentand selective drugs that negate drug resistance, with less d... Read More about Design of new anticancer drugs by selectable intracellular organelle targeting: make for the mitochondria or turn left for the lysosome?.