All Outputs (5)

Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria (2024)
Journal Article
Surendran, A., Turnbull, A., Flockhart, A., Findlay-Greene, F., Nowosielska, M., Morrison, D., Mincher, D. J., & Donnellan, S. (2024). Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria. All Life, 17(1), Article 2379309. https://doi.org/10.1080/26895293.2024.2379309

We hypothesise that antimicrobial resistance (AMR) cannot be overcome by simply ‘drugging’ single biological targets, therefore, our focus is developing broad-spectrum therapeutics. Herein we present the synthesis of two novel spacer-linked, anthraqu... Read More about Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria.

Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle (2021)
Journal Article
Wheelhouse, N., Hearn, J., Livingstone, M., Flockhart, A., Dagleish, M., & Longbottom, D. (2022). Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle. Journal of Applied Microbiology, 132(4), 2642-2648. https://doi.org/10.1111/jam.15422

Aims The order Chlamydiales comprises a broad range of bacterial pathogens and endosymbionts, which infect a wide variety of host species. Within this order, members of the family Parachlamydiaceae, which includes Parachlamydia and Neochlamydia spec... Read More about Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle.

Presence of DNA from Chlamydia-like organisms in the nasal cavities of grey seal pups (Halichoerus grypus) and three different substrates present in a breeding colony (2021)
Journal Article
Dagleish, M. P., Flockhart, A. F., Baily, J. L., Hall, A. J., Simpson, T. I., & Longbottom, D. (2021). Presence of DNA from Chlamydia-like organisms in the nasal cavities of grey seal pups (Halichoerus grypus) and three different substrates present in a breeding colony. BMC Veterinary Research, 17(1), Article 328. https://doi.org/10.1186/s12917-021-03032-3

Background Chlamydia-like organisms (CLO) have been found to be present in many environmental niches, including human sewage and agricultural run-off, as well as in a number of aquatic species worldwide. Therefore, monitoring their presence in senti... Read More about Presence of DNA from Chlamydia-like organisms in the nasal cavities of grey seal pups (Halichoerus grypus) and three different substrates present in a breeding colony.

Isolation of Streptococcus Mutans and its Bacteriophage from Human Plaque Samples (2019)
Journal Article
Ahmed, H., Flockhart, A., Foley, S., & Foley, J. (2019). Isolation of Streptococcus Mutans and its Bacteriophage from Human Plaque Samples. Saudi Journal of Oral and Dental Research, 4(8), 561-564. https://doi.org/10.21276/sjodr.2019.4.8.10

Background: Streptococcus mutans (S. mutans) is one of the main agents of caries formation, mainly because of the ability to form biofilms on the tooth surface. Bacteriophage of S. mutans are viruses that can attack and limit the pathogenic activity... Read More about Isolation of Streptococcus Mutans and its Bacteriophage from Human Plaque Samples.

Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila (2016)
Journal Article
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports, 6, 37150. https://doi.org/10.1038/srep37150

Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in cattle. Despite an increasing number of observational studies linking W. chondr... Read More about Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila.