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Single-photon emission computed tomography with 99mTc-exametazime in unmediated schizophrenic patients

Ebmeier, K P; Blackwood, D H R; Murray, C; Souza, V; Walker, M; Dougall, N; Moffoot, A P R; O'Carroll, R E; Goodwin, G M

Authors

K P Ebmeier

D H R Blackwood

C Murray

V Souza

M Walker

A P R Moffoot

R E O'Carroll

G M Goodwin



Abstract

We examined 20 actively psychotic unmedicated schizophrenic patients and 20 matched control subjects by using single-photon emission, computed tomography (SPECT) with 99mtechnetium-exametazime. Patients showed a hyperfrontal pattern of tracer uptake with significant relative increases in superior prefrontal cortex. This abnormality was less pronounced in patients with higher symptom scores for psychomotor poverty. In addition, patients showed associations between certain schizophrenic syndrome scores, such as psychomotor poverty, disorganization, and reality distortion, and tracer uptake to a number of cortical and subcortical brain regions. This syndrome-related pattern of tracer uptake was, at least in part, consistent with similar associations previously reported in chronically medicated schizophrenic patients. SPECT therefore provides a readily available method to examine the relationship between symptom pattern and regional brain metabolism in psychotic patients. Any observed patterns of association will depend on the current mental and medication status of the patients examined.

Citation

Ebmeier, K. P., Blackwood, D. H. R., Murray, C., Souza, V., Walker, M., Dougall, N., Moffoot, A. P. R., O'Carroll, R. E., & Goodwin, G. M. (1993). Single-photon emission computed tomography with 99mTc-exametazime in unmediated schizophrenic patients. Biological Psychiatry, 33(7), 487-495. https://doi.org/10.1016/0006-3223%2893%2990002-u

Journal Article Type Article
Acceptance Date Jan 1, 1993
Publication Date 1993-04
Deposit Date Sep 30, 2016
Journal Biological Psychiatry
Print ISSN 0006-3223
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 33
Issue 7
Pages 487-495
DOI https://doi.org/10.1016/0006-3223%2893%2990002-u
Keywords Single-photon emission tomography; schizophrenia; cerebral blood flow
Public URL http://researchrepository.napier.ac.uk/Output/396576



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