Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis

Booth, Joanne; Connelly, Lesley; Lawrence, Maggie; Chalmers, Campbell; Joice, Sara; Becker, Clarissa; Dougall, Nadine

doi:10.1186/s12883-015-0456-4

Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis

Booth, Joanne; Connelly, Lesley; Lawrence, Maggie; Chalmers, Campbell; Joice, Sara; Becker, Clarissa; Dougall, Nadine

Authors

Joanne Booth

Lesley Connelly

Maggie Lawrence

Campbell Chalmers

Sara Joice

Clarissa Becker

Prof Nadine Dougall N.Dougall@napier.ac.uk
Professor

Abstract

Background
Several studies suggest that perceived psychosocial stress is associated with increased risk of stroke; however results are inconsistent with regard to definitions and measurement of perceived stress, features of individual study design, study conduct and conclusions drawn and no meta-analysis has yet been published. We performed a systematic review and meta-analysis of studies assessing association between perceived psychosocial stress and risk of stroke in adults.The results of the meta-analysis are presented.

Methods
Systematic searches of MEDLINE, EMBASE, CINAHL, PsycInfo, and Cochrane Database of Systematic Reviews were undertaken between 1980 and June 2014. Data extraction and quality appraisal was performed by two independent reviewers. Hazard ratios (HR) and odds ratios (OR) were pooled where appropriate.

Results
14 studies were included in the meta-analysis, 10 prospective cohort, 4 case–control design. Overall pooled adjusted effect estimate for risk of total stroke in subjects exposed to general or work stress or to stressful life events was 1.33 (95 % confidence interval [CI], 1.17, 1.50; P 0.0001).A sex difference was noted with higher stroke risk identified for women (HR 1.90 95 % CI, 1.4, 2.56: P

Citation

Booth, J., Connelly, L., Lawrence, M., Chalmers, C., Joice, S., Becker, C., & Dougall, N. (2015). Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis. BMC Neurology, 15(1), https://doi.org/10.1186/s12883-015-0456-4

Journal Article Type	Article
Acceptance Date	Oct 2, 2015
Online Publication Date	Nov 12, 2015
Publication Date	2015-12
Deposit Date	Sep 1, 2016
Journal	BMC Neurology
Electronic ISSN	1471-2377
Publisher	BMC
Peer Reviewed	Peer Reviewed
Volume	15
Issue	1
DOI	https://doi.org/10.1186/s12883-015-0456-4
Keywords	Stress, Psychological Stroke Risk factor
Public URL	http://researchrepository.napier.ac.uk/Output/369515