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Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis

Booth, Joanne; Connelly, Lesley; Lawrence, Maggie; Chalmers, Campbell; Joice, Sara; Becker, Clarissa; Dougall, Nadine


Joanne Booth

Lesley Connelly

Maggie Lawrence

Campbell Chalmers

Sara Joice

Clarissa Becker


Several studies suggest that perceived psychosocial stress is associated with increased risk of stroke; however results are inconsistent with regard to definitions and measurement of perceived stress, features of individual study design, study conduct and conclusions drawn and no meta-analysis has yet been published. We performed a systematic review and meta-analysis of studies assessing association between perceived psychosocial stress and risk of stroke in adults.The results of the meta-analysis are presented.

Systematic searches of MEDLINE, EMBASE, CINAHL, PsycInfo, and Cochrane Database of Systematic Reviews were undertaken between 1980 and June 2014. Data extraction and quality appraisal was performed by two independent reviewers. Hazard ratios (HR) and odds ratios (OR) were pooled where appropriate.

14 studies were included in the meta-analysis, 10 prospective cohort, 4 case–control design. Overall pooled adjusted effect estimate for risk of total stroke in subjects exposed to general or work stress or to stressful life events was 1.33 (95 % confidence interval [CI], 1.17, 1.50; P  0.0001).A sex difference was noted with higher stroke risk identified for women (HR 1.90 95 % CI, 1.4, 2.56: P 


Booth, J., Connelly, L., Lawrence, M., Chalmers, C., Joice, S., Becker, C., & Dougall, N. (2015). Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis. BMC Neurology, 15(1),

Journal Article Type Article
Acceptance Date Oct 2, 2015
Online Publication Date Nov 12, 2015
Publication Date 2015-12
Deposit Date Sep 1, 2016
Journal BMC Neurology
Electronic ISSN 1471-2377
Publisher BMC
Peer Reviewed Peer Reviewed
Volume 15
Issue 1
Keywords Stress, Psychological Stroke Risk factor
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