Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial

Ingle, Lee; Powell, Richard; Begg, Brian; Birkett, Stefan T; Nichols, Simon; Ennis, Stuart; Banerjee, Pritwish; Shave, Rob; McGregor, Gordon

Abstract

The objective of this study was to compare the characteristics of responders and nonresponders to 8 weeks of exercise training, to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD). This was undertaken via secondary analysis of data from the HIIT or MISS UK trial, focusing on six outpatient National Health Service cardiac rehabilitation (CR) centers in the UK. In people with CAD attending CR, the HIIT or MISS UK trial reported that short-term, low-volume, high-intensity interval training (HIIT) was more effective than moderate-intensity steady state (MISS) exercise training for improving peak oxygen uptake (VO2peak). The study involved 382 participants with CAD (N=382) (mean age: 58.8±9.6y; mean body mass index: 29.0±4.3 kg/m2). We identified responders and nonresponders based on a meaningful change in VO2peak, using two established methods. Key clinical, quality of life (QoL), and cardiopulmonary exercise test (CPET)–derived outcomes were compared between groups. The study found that responders were more likely to be younger (P<.05), and demonstrate greater improvement in CPET-related outcomes, for example, oxygen uptake efficiency slope, ventilatory efficiency, and peak power output (all comparisons, P<.001). Responders were more likely to observe improvements in QoL (EQ-5D-5L; mean Δ 13.6 vs mean Δ 9.4; P=.045), and high-density lipoprotein cholesterol (HDL-c) (mean Δ 0.09 mmol/L vs mean Δ 0.04 mmol/L; P=.004), compared to nonresponders. In people with CAD attending CR, responders to exercise training were therefore more likely to be younger and demonstrate greater improvements in health-related QoL and HDL-c.

Citation

Ingle, L., Powell, R., Begg, B., Birkett, S. T., Nichols, S., Ennis, S., Banerjee, P., Shave, R., & McGregor, G. (2024). Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial. Archives of Physical Medicine and Rehabilitation, 105(8), 1464-1470. https://doi.org/10.1016/j.apmr.2024.03.002

• Journal Article Type: Article
• Acceptance Date: Mar 4, 2024
• Online Publication Date: Mar 15, 2024
• Publication Date: 2024-08
• Deposit Date: Nov 5, 2024
• Journal: Archives of Physical Medicine and Rehabilitation
• Print ISSN: 0003-9993
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 105
• Issue: 8
• Pages: 1464-1470
• DOI: https://doi.org/10.1016/j.apmr.2024.03.002
• Keywords: Exercise dose, Exercise prescription, Heart disease, HIIT, Intensity, Training volume