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Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression

Coon, H.; Hicks, A. A.; Bailey, M. E.S.; Hoff, M.; Holik, J.; Harvey, R. J.; Johnson, K. J.; Darlison, M. G.; Reimherr, F.; Wender, P.; Byerley, W.

Authors

H. Coon

A. A. Hicks

M. E.S. Bailey

M. Hoff

J. Holik

R. J. Harvey

K. J. Johnson

M. G. Darlison

F. Reimherr

P. Wender

W. Byerley



Abstract

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABAA receptor α1, α2, α4, α5, α6, β1, β3 and γ2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found.

Citation

Coon, H., Hicks, A. A., Bailey, M. E., Hoff, M., Holik, J., Harvey, R. J., Johnson, K. J., Darlison, M. G., Reimherr, F., Wender, P., & Byerley, W. (1994). Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression. Psychiatric Genetics, 4(3), 185-191. https://doi.org/10.1097/00041444-199400430-00009

Journal Article Type Article
Acceptance Date Jan 1, 1994
Publication Date 1994
Deposit Date Aug 5, 2016
Journal Psychiatric Genetics
Print ISSN 0955-8829
Electronic ISSN 1473-5873
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 4
Issue 3
Pages 185-191
DOI https://doi.org/10.1097/00041444-199400430-00009
Keywords Genetics(clinical); Genetics; Biological Psychiatry; Psychiatry and Mental health
Public URL http://researchrepository.napier.ac.uk/Output/328092






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