Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression

Coon, H.; Hicks, A. A.; Bailey, M. E.S.; Hoff, M.; Holik, J.; Harvey, R. J.; Johnson, K. J.; Darlison, M. G.; Reimherr, F.; Wender, P.; Byerley, W.

Abstract

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABAA receptor α1, α2, α4, α5, α6, β1, β3 and γ2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found.

Citation

Coon, H., Hicks, A. A., Bailey, M. E., Hoff, M., Holik, J., Harvey, R. J., Johnson, K. J., Darlison, M. G., Reimherr, F., Wender, P., & Byerley, W. (1994). Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression. Psychiatric Genetics, 4(3), 185-191. https://doi.org/10.1097/00041444-199400430-00009

• Journal Article Type: Article
• Acceptance Date: Jan 1, 1994
• Publication Date: 1994
• Deposit Date: Aug 5, 2016
• Journal: Psychiatric Genetics
• Print ISSN: 0955-8829
• Electronic ISSN: 1473-5873
• Publisher: Lippincott, Williams & Wilkins
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 3
• Pages: 185-191
• DOI: https://doi.org/10.1097/00041444-199400430-00009
• Keywords: Genetics(clinical); Genetics; Biological Psychiatry; Psychiatry and Mental health
• Public URL: http://researchrepository.napier.ac.uk/Output/328092