Rheometry and associated techniques for blood coagulation studies

Evans, P A; Hawkins, K; Lawrence, M; Williams, R L; Barrow, M S; Thirumalai, N; Williams, P R

Abstract

This review considers various rheometrical approaches that have been adopted to study blood coagulation, with special reference to the rheological assessment of clotting time and studies of the evolution of viscoelasticity during the course of fibrin polymerization and cross-linking. The significance of the Gel Point in blood coagulation studies is discussed as a common feature of many of these studies in that they attempt to detect a liquid-to-solid transition during coagulation. Coagulation studies based on various forms of complex shear modulus measurements are considered, the latter being based principally on controlled stress and controlled strain rheometers. Also considered are the long established technique of thromboelastography and several emerging techniques such as wave propagation measurements, free oscillation rheometry, quartz crystal microbalance measurements and surface plasmon resonance.

Citation

Evans, P. A., Hawkins, K., Lawrence, M., Williams, R. L., Barrow, M. S., Thirumalai, N., & Williams, P. R. (2008). Rheometry and associated techniques for blood coagulation studies. Medical engineering & physics, 30(6), 671-679. https://doi.org/10.1016/j.medengphy.2007.08.005

• Journal Article Type: Article
• Acceptance Date: Aug 14, 2007
• Online Publication Date: Sep 27, 2007
• Publication Date: 2008-07
• Deposit Date: Aug 1, 2016
• Journal: Medical Engineering & Physics
• Electronic ISSN: 1350-4533
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 6
• Pages: 671-679
• DOI: https://doi.org/10.1016/j.medengphy.2007.08.005
• Keywords: Blood coagulation; Clot viscoelasticity, Incipient clot, Gel Point, Clot formation time, Blood clot detection,
• Public URL: http://researchrepository.napier.ac.uk/Output/320661