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Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training

Yasar, Zerbu; Ross, Mark D.; Gaffney, Christopher J.; Postlethwaite, Ruth D.; Wilson, Russell; Hayes, Lawrence D.

Authors

Zerbu Yasar

Mark D. Ross

Christopher J. Gaffney

Ruth D. Postlethwaite

Russell Wilson

Lawrence D. Hayes



Abstract

Older adults exhibit a reduced number and function of CD34 + circulating progenitor cells (CPC), a known risk factor for cardiovascular disease. Exercise promotes the mobilisation of CPCs from bone marrow, so whether ageing per se or physical inactivity in older age reduces CPCs is unknown. Thus, this study examined the effect of age on resting and exercise-induced changes in CPCs in aerobically trained adults and the effect of 8 weeks of sprint interval training (SIT) on resting and exercise-induced CPCs in older adults. Twelve young (22–34 years) and nine older (63–70 years) adults participated in the study. Blood was sampled pre and immediately post a graded exercise test to exhaustion in both groups. Older participants repeated the process after 8 weeks of SIT (3 × 20 s ‘all-out’ sprints, 2 × a week). Total CPCs (CD34+) and endothelial progenitor cells (EPCs: CD34+KDR+) were determined by flow cytometry. Older adults exhibited lower basal total CD34+ CPCs (828 ± 314 vs. 1186 ± 272 cells·mL−1, p = 0.0149) and CD34+KDR+ EPCs (177 ± 128 vs. 335 ± 92 cells·mL−1, p = 0.007) than younger adults. The maximal exercise test increased CPCs in young (CD34+: p = 0.004; CD34+KDR+: p = 0.017) and older adults (CD34+: p < 0.001; CD34+KDR+: p = 0.008), without difference between groups (p = 0.211). SIT did not alter resting or exercise-induced changes in CPCs in the older cohort (p > 0.232). This study suggests age per se does not impair exercise-induced CPC counts, but does lower resting CPC counts.

Journal Article Type Article
Acceptance Date Dec 19, 2022
Online Publication Date Feb 14, 2023
Publication Date 2023-04
Deposit Date Mar 10, 2023
Publicly Available Date Mar 10, 2023
Print ISSN 0031-6768
Electronic ISSN 1432-2013
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 475
Issue 4
Pages 465-475
DOI https://doi.org/10.1007/s00424-022-02785-6
Keywords Ageing, Endothelial, Endothelial progenitor cells, HIIT, Sprint, Vascular

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