Skip to main content

Research Repository

Advanced Search

Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise

Brown, Frankie F.; Bigley, Austin B.; Sherry, Chris; Neal, Craig M.; Witard, Oliver C.; Simpson, Richard J.; Galloway, Stuart D.R.


Frankie F. Brown

Austin B. Bigley

Chris Sherry

Craig M. Neal

Oliver C. Witard

Richard J. Simpson

Stuart D.R. Galloway


Investigate training status and sex effects on the redistribution of senescent and naïve T-lymphocytes following acute exercise.

Sixteen (8 male, 8 female) trained (18.3 ± 1.7 yr) soccer players (Tr) and sixteen (8 male, 8 female) untrained (19.3 ± 2.0 yr) controls (UTr) performed a treadmill running test to volitional exhaustion. Blood lymphocytes were isolated before (Pre), immediately post, and 1-h post-exercise for assessment of cell surface expression of CD28 and CD57 on CD4+ and CD8+ T-lymphocyte subsets. Plasma was used to determine cytomegalovirus (CMV) serostatus.

Exercise elicited a redistribution of T-lymphocyte subsets. Senescent CD4+ and CD8+ T-lymphocytes increased by 42.4% and 45.9% respectively, while naïve CD4+ and CD8+ T-lymphocytes decreased by 8.7% and 22.5% respectively in response to exercise. A main effect (P < 0.05) of training status was observed for senescent CD4+, CD8+ and naïve CD8+ T-lymphocytes: UTr had a higher proportion of senescent and a lower proportion of naïve CD8+ T-lymphocytes than Tr. A main effect (P < 0.05) of sex was observed in senescent CD4+, CD8+ and naïve CD4+, CD8+ T-lymphocytes. Males had a higher proportion of senescent and lower proportion of naïve T-lymphocytes than females. A sex-by-training status interaction (P < 0.05) was observed for the senescent and naïve CD4+ T-lymphocytes (but not CD8+) with the highest percentage of senescent and lowest percentage of naïve T-lymphocytes observed in UTr males. CMV exerted a significant main covariate effect (P < 0.05) in the senescent and naïve (P < 0.05) CD8+ T-lymphocytes but not in the senescent and naïve CD4+ T-lymphocytes.

This study highlights important sex and training status differences in the senescent and naïve T-lymphocyte redistribution in response to exercise that warrants further investigation.

Journal Article Type Article
Online Publication Date Nov 4, 2013
Publication Date 2014-07
Deposit Date Jan 12, 2023
Journal Brain, Behavior, and Immunity
Print ISSN 0889-1591
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 39
Pages 152-159