Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise

Brown, Frankie F.; Bigley, Austin B.; Sherry, Chris; Neal, Craig M.; Witard, Oliver C.; Simpson, Richard J.; Galloway, Stuart D.R.

Abstract

Purpose
Investigate training status and sex effects on the redistribution of senescent and naïve T-lymphocytes following acute exercise.

Methods
Sixteen (8 male, 8 female) trained (18.3 ± 1.7 yr) soccer players (Tr) and sixteen (8 male, 8 female) untrained (19.3 ± 2.0 yr) controls (UTr) performed a treadmill running test to volitional exhaustion. Blood lymphocytes were isolated before (Pre), immediately post, and 1-h post-exercise for assessment of cell surface expression of CD28 and CD57 on CD4+ and CD8+ T-lymphocyte subsets. Plasma was used to determine cytomegalovirus (CMV) serostatus.

Results
Exercise elicited a redistribution of T-lymphocyte subsets. Senescent CD4+ and CD8+ T-lymphocytes increased by 42.4% and 45.9% respectively, while naïve CD4+ and CD8+ T-lymphocytes decreased by 8.7% and 22.5% respectively in response to exercise. A main effect (P < 0.05) of training status was observed for senescent CD4+, CD8+ and naïve CD8+ T-lymphocytes: UTr had a higher proportion of senescent and a lower proportion of naïve CD8+ T-lymphocytes than Tr. A main effect (P < 0.05) of sex was observed in senescent CD4+, CD8+ and naïve CD4+, CD8+ T-lymphocytes. Males had a higher proportion of senescent and lower proportion of naïve T-lymphocytes than females. A sex-by-training status interaction (P < 0.05) was observed for the senescent and naïve CD4+ T-lymphocytes (but not CD8+) with the highest percentage of senescent and lowest percentage of naïve T-lymphocytes observed in UTr males. CMV exerted a significant main covariate effect (P < 0.05) in the senescent and naïve (P < 0.05) CD8+ T-lymphocytes but not in the senescent and naïve CD4+ T-lymphocytes.

Conclusion
This study highlights important sex and training status differences in the senescent and naïve T-lymphocyte redistribution in response to exercise that warrants further investigation.

Citation

Brown, F. F., Bigley, A. B., Sherry, C., Neal, C. M., Witard, O. C., Simpson, R. J., & Galloway, S. D. (2014). Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise. Brain, Behavior, and Immunity, 39, 152-159. https://doi.org/10.1016/j.bbi.2013.10.031

• Journal Article Type: Article
• Online Publication Date: Nov 4, 2013
• Publication Date: 2014-07
• Deposit Date: Jan 12, 2023
• Journal: Brain, Behavior, and Immunity
• Print ISSN: 0889-1591
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 39
• Pages: 152-159
• DOI: https://doi.org/10.1016/j.bbi.2013.10.031