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Modelling the restoration of activity in a biological neural network

Dos Santos, Filipa; Steyn, Jannetta S.; Andras, Peter

Authors

Filipa Dos Santos

Jannetta S. Steyn

Profile image of Peter Andras

Prof Peter Andras P.Andras@napier.ac.uk
Dean of School of Computing Engineering and the Built Environment



Abstract

Understanding the mechanisms of restoration of activity in biological neural systems following exposure to damage is key for design of future neuro-prosthetic devices and restorative treatments. The pyloric rhythm network within the crustacean stomatogastric ganglion is a biological neural system that shows spontaneous restoration of activity following the stopping of inputs from higher control ganglia. We model the restoration of the activity in this network using conductance-based models of neurons and the alteration of conductance parameters of the model. Our analysis shows that this approach works only if some of the conductance values remain constrained following the stopping of higher inputs. Our model also shows that in order to model the restoration of the activity in this network it is not necessary to rely on complicated alterations of the mechanisms of Calcium ionic currents in the model, which was proposed previously.

Citation

Dos Santos, F., Steyn, J. S., & Andras, P. (2016, July). Modelling the restoration of activity in a biological neural network. Presented at 2016 International Joint Conference on Neural Networks (IJCNN), Vancouver, BC, Canada

Presentation Conference Type Conference Paper (published)
Conference Name 2016 International Joint Conference on Neural Networks (IJCNN)
Start Date Jul 24, 2016
End Date Jul 29, 2016
Online Publication Date Nov 3, 2016
Publication Date 2016
Deposit Date Nov 10, 2021
Publisher Institute of Electrical and Electronics Engineers
Pages 4672-4679
Series ISSN 2161-4407
Book Title 2016 International Joint Conference on Neural Networks (IJCNN)
DOI https://doi.org/10.1109/IJCNN.2016.7727813
Keywords biological neural network, conductance-based model, neural activity restoration, stomatogastric ganglion
Public URL http://researchrepository.napier.ac.uk/Output/2809213