Low molecular weight Neutral Boron Dipyrromethene (Bodipy) dyads for fluorescence-based neural imaging

Bai, Dan; Benniston, Andrew C; Clift, Sophie; Baisch, Ulrich; Steyn, Jannetta; Everitt, Nicola; Andras, Peter

Abstract

The neutral low molecular weight julolidine-based borondipyrromethene (Bodipy) dyads JULBD and MJULBD were used for fast voltage-sensitive dye imaging of neurons in the crab stomatogastric ganglion. The fluorescence modulation of the dyads mirrors alterations in the membrane potential of the imaged neurons. The toxicity of the dyes towards the neurons is related to their structure in that methyl groups at the 3,5 positions results in reduced toxic effects.

Citation

Bai, D., Benniston, A. C., Clift, S., Baisch, U., Steyn, J., Everitt, N., & Andras, P. (2014). Low molecular weight Neutral Boron Dipyrromethene (Bodipy) dyads for fluorescence-based neural imaging. Journal of Molecular Structure, 1065-1066, 10-15. https://doi.org/10.1016/j.molstruc.2014.02.026

• Journal Article Type: Article
• Acceptance Date: Feb 14, 2014
• Online Publication Date: Feb 22, 2014
• Publication Date: 2014-05
• Deposit Date: Nov 2, 2021
• Journal: Journal of Molecular Structure
• Print ISSN: 0022-2860
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 1065-1066
• Pages: 10-15
• DOI: https://doi.org/10.1016/j.molstruc.2014.02.026
• Keywords: Bodipy, Fluorescence, Neural imaging, Structure, Electrochemistry
• Public URL: http://researchrepository.napier.ac.uk/Output/2809069