A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Deal, Jennifer A.; Albert, Marilyn S.; Arnold, Michelle; Bangdiwala, Shrikant I.; Chisolm, Theresa; Davis, Sonia; Eddins, Ann; Glynn, Nancy W.; Goman, Adele M.; Minotti, Melissa; Mosley, Thomas; Rebok, George W.; Reed, Nicholas; Rodgers, Elizabeth; Sanchez, Victoria; Sharrett, A. Richey; Coresh, Josef; Lin, Frank R.

Abstract

Introduction
Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults.

Methods
A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254.

Results
The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD).

Discussion
ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

Citation

Deal, J. A., Albert, M. S., Arnold, M., Bangdiwala, S. I., Chisolm, T., Davis, S., Eddins, A., Glynn, N. W., Goman, A. M., Minotti, M., Mosley, T., Rebok, G. W., Reed, N., Rodgers, E., Sanchez, V., Sharrett, A. R., Coresh, J., & Lin, F. R. (2017). A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(3), 410-415. https://doi.org/10.1016/j.trci.2017.06.003

• Journal Article Type: Article
• Online Publication Date: Jun 21, 2017
• Publication Date: 2017-09
• Deposit Date: Oct 7, 2021
• Publicly Available Date: Jun 27, 2023
• Journal: Alzheimer's & Dementia: Translational Research & Clinical Interventions
• Print ISSN: 2352-8737
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 3
• Pages: 410-415
• DOI: https://doi.org/10.1016/j.trci.2017.06.003
• Keywords: Psychiatry and Mental health; Clinical Neurology
• Public URL: http://researchrepository.napier.ac.uk/Output/2808268