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Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial

Pike, James Russell; Huang, Alison R.; Reed, Nicholas S.; Arnold, Michelle; Chisolm, Theresa; Couper, David; Deal, Jennifer A.; Glynn, Nancy W.; Goman, Adele M.; Hayden, Kathleen M.; Mitchell, Christine M.; Pankow, James S.; Sanchez, Victoria; Sullivan, Kevin J.; Tan, Nasya S.; Coresh, Josef; Lin, Frank R.

Authors

James Russell Pike

Alison R. Huang

Nicholas S. Reed

Michelle Arnold

Theresa Chisolm

David Couper

Jennifer A. Deal

Nancy W. Glynn

Kathleen M. Hayden

Christine M. Mitchell

James S. Pankow

Victoria Sanchez

Kevin J. Sullivan

Nasya S. Tan

Josef Coresh

Frank R. Lin



Abstract

INTRODUCTION: Results from the ACHIEVE trial suggest hearing intervention may not reduce 3-year cognitive decline in all older adults with hearing loss but may be beneficial in certain groups. This secondary analysis investigated if participants with multiple risk factors for cognitive decline received greater benefits.
METHODS: We used a sample of dementia-free participants (N=2,692) from the ARIC cohort to develop a predictive model for cognitive decline. The model was applied to baseline measures of ACHIEVE participants (N=977) to estimate predicted risk. We tested an interaction between predicted risk and randomization to hearing intervention or health education control.
RESULTS: Among ACHIEVE participants in the top quartile of predicted risk, 3-year cognitive decline in the hearing intervention was 61.6% (95% CI 33.7%, 94.1%) slower than the control.
DISCUSSION: The effect of hearing intervention on reducing 3-year cognitive decline was greatest among individuals with multiple baseline risk factors associated with faster cognitive decline.
Trial Registration: ClinicalTrials.gov Identifier: NCT03243422

Citation

Pike, J. R., Huang, A. R., Reed, N. S., Arnold, M., Chisolm, T., Couper, D., Deal, J. A., Glynn, N. W., Goman, A. M., Hayden, K. M., Mitchell, C. M., Pankow, J. S., Sanchez, V., Sullivan, K. J., Tan, N. S., Coresh, J., & Lin, F. R. (in press). Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial. Alzheimer's & Dementia: The Journal of the Alzheimer's Association,

Journal Article Type Article
Acceptance Date Mar 12, 2025
Deposit Date Mar 25, 2025
Print ISSN 1552-5260
Electronic ISSN 1552-5279
Publisher Wiley
Peer Reviewed Peer Reviewed
Public URL http://researchrepository.napier.ac.uk/Output/4186969

This file is under embargo due to copyright reasons.

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