Origins of Staphylococcus epidermidis and Streptococcus oralis causing bacteraemia in a bone marrow transplant patient.

Kennedy, H F; Morrison, Donald; Kaufmann, M E; Jackson, M S; Bagg, J; Gibson, B E; Gemmell, C G; Michie, J R

Origins of Staphylococcus epidermidis and Streptococcus oralis causing bacteraemia in a bone marrow transplant patient.

Kennedy, H F; Morrison, Donald; Kaufmann, M E; Jackson, M S; Bagg, J; Gibson, B E; Gemmell, C G; Michie, J R

Authors

H F Kennedy

Dr Donald Morrison D.Morrison2@napier.ac.uk
Associate Professor

M E Kaufmann

M S Jackson

J Bagg

B E Gibson

C G Gemmell

J R Michie

Abstract

Coagulase-negative staphylococcal bacteraemia in immunocompromised patients is often associated with the use of central venous catheters, while the proposed origin of viridans streptococci causing bacteraemia in this patient group is the oral cavity. This report describes an episode of polymicrobial bacteraemia caused by Staphylococcus epidermidis and Streptococcus oralis followed by several further episodes of S. epidermidis bacteraemia in a 15-year-old boy after bone marrow transplantation. Pulsed-field gel electrophoresis (PFGE) of SmaI chromosomal DNA digests was used to compare blood culture and oral isolates of S. epidermidis and Str. oralis. The results indicated that the mouth was the source of both S. epidermidis and Str. oralis causing the first episode of bacteraemia. PFGE further demonstrated that the central venous catheter was the origin of a second strain of S. epidermidis responsible for subsequent episodes of staphylococcal bacteraemia. Both the oral mucosa and central venous lines should be considered as potential sources of organisms, including coagulase-negative staphylococci, associated with bacteraemia in immunocompromised patients.

Citation

Kennedy, H. F., Morrison, D., Kaufmann, M. E., Jackson, M. S., Bagg, J., Gibson, B. E., Gemmell, C. G., & Michie, J. R. (2000). Origins of Staphylococcus epidermidis and Streptococcus oralis causing bacteraemia in a bone marrow transplant patient. Journal of Medical Microbiology, 49, 367-370

Journal Article Type	Article
Publication Date	2000
Deposit Date	Jun 11, 2015
Print ISSN	0022-2615
Electronic ISSN	1473-5644
Publisher	Microbiology Society
Peer Reviewed	Peer Reviewed
Volume	49
Pages	367-370
Keywords	Coagulase-negative staphylococcal bacteraemia; Staphylococcus epidermidis; Streptococcus oralis; Pulsed-field gel electrophoresis (PFGE); SmaI chromosomal DNA digests;
Public URL	http://researchrepository.napier.ac.uk/id/eprint/8661