Bacteriostatic activity of human lactoferrin  against Staphylococcus aureusis a function of its iron-binding properties and is not influenced by antibiotic resistance.

Aguila, Antonio; Herrera, Ana G; Morrison, Donald; Cosgrove, Bonnie; Perojo, Alicia; Montesinos, Isis; Perez, Julian; Sierra, Gustavo; Gemmell, Curtis G; Brock, Jeremy H

doi:10.1111/j.1574-695X.2001.tb00511.x

Bacteriostatic activity of human lactoferrin against Staphylococcus aureusis a function of its iron-binding properties and is not influenced by antibiotic resistance.

Aguila, Antonio; Herrera, Ana G; Morrison, Donald; Cosgrove, Bonnie; Perojo, Alicia; Montesinos, Isis; Perez, Julian; Sierra, Gustavo; Gemmell, Curtis G; Brock, Jeremy H

Authors

Antonio Aguila

Ana G Herrera

Dr Donald Morrison D.Morrison2@napier.ac.uk
Associate Professor

Bonnie Cosgrove

Alicia Perojo

Isis Montesinos

Julian Perez

Gustavo Sierra

Curtis G Gemmell

Jeremy H Brock

Abstract

The in vitro antistaphylococcal activity of lactoferrin and the antibiotic resistance of clinical Staphylococcus aureus isolates obtained from three different sites of infection were examined. Antibiotic, but not lactoferrin resistance correlated with selective antibiotic pressure, and nosocomial and most community isolates were antibiotic resistant, whereas only a third of each group was resistant to lactoferrin. The antimicrobial activity of lactoferrin, both in defined medium and in normal human plasma serum, was dependent upon its ferrochelating properties. Therapeutic approaches based on the use of ferrochelating agents such as lactoferrin combined with antimicrobial drugs may help to counteract the reduced efficacy of current antibiotics.

Citation

Aguila, A., Herrera, A. G., Morrison, D., Cosgrove, B., Perojo, A., Montesinos, I., Perez, J., Sierra, G., Gemmell, C. G., & Brock, J. H. (2001). Bacteriostatic activity of human lactoferrin against Staphylococcus aureusis a function of its iron-binding properties and is not influenced by antibiotic resistance. FEMS Immunology and Medical Microbiology, 31, 145-152. https://doi.org/10.1111/j.1574-695X.2001.tb00511.x

Journal Article Type	Article
Publication Date	2001
Deposit Date	Jun 11, 2015
Print ISSN	0928-8244
Electronic ISSN	1574-695X
Publisher	Oxford University Press
Peer Reviewed	Peer Reviewed
Volume	31
Pages	145-152
DOI	https://doi.org/10.1111/j.1574-695X.2001.tb00511.x
Keywords	Antibiotic; Antimicrobial activity; Iron; Lactoferrin; MRSA; Staphylococcus aureus;
Public URL	http://researchrepository.napier.ac.uk/id/eprint/8662
Publisher URL	http://dx.doi.org/10.1111/j.1574-695X.2001.tb00511.x