Coordinated graph and scatter-plot views for the visual exploration of microarray time-series data

Craig, P.; Kennedy, J.

Abstract

Microarrays are a relatively new, high-throughput data acquisition technology for investigating biological phenomena at the micro-level. The product of microarray experiments is large-scale time-series data, which subject to proper analysis has the potential to have significant impact on the diagnosis, treatment, and prevention of diseases. While existing information visualization techniques go some way to making microarray time-series data more manageable, requirements analysis has revealed significant limitations. The main finding was that users were unable to uncover and quantify common changes in value over a specified time-period. This paper describes a novel technique that provides this functionality by allowing the user to visually formulate and modify measurable queries with separate time-period and condition components. These visual queries are supported by the combination of a traditional value against time graph representation of the data with a complementary scatter-plot representation of a specified time-period. The multiple views of the visualization are coordinated so that the user can formulate and modify queries with rapid reversible display of query results in the traditional value against time graph format.

• Presentation Conference Type: Conference Paper (Published)
• Conference Name: IEEE Symposium on Information Visualization 2003 (IEEE Cat. No.03TH8714)
• Start Date: Oct 21, 2003
• End Date: Oct 21, 2003
• Publication Date: 2003
• Deposit Date: Oct 28, 2009
• Publicly Available Date: Oct 28, 2009
• Publisher: Institute of Electrical and Electronics Engineers
• Peer Reviewed: Peer Reviewed
• Pages: 173-180
• Book Title: IEEE Symposium on Information Visualization
• ISBN: 0780381548
• DOI: https://doi.org/10.1109/infvis.2003.1249023
• Keywords: Bioinformatics; Microarrays; Information Visualization; Time-Series; Multiple-views; Multiple time-specific criteria; Scatter plots
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/3020
• Publisher URL: http://dx.doi.org/10.1109/INFVIS.2003.1249023
• Contract Date: Oct 28, 2009