Improvement of Retinal Function after Administration of an Ophthalmic Gel Containing a New Recombinant form of Superoxide Dismutase

Grumetto, Lucia; Prete, Antonio Del; Russo, Giacomo; Borrelli, Antonella; Del Prete, Salvatore; Mancini, Aldo

Abstract

Two cases of severe age-related eye maculopathy diagnosed in a 73-year-old and a 53-year-old patient are presented. A gel formulation containing a new recombinant form of manganese superoxide dismutase (rMnSOD) was administered to both patients, as compassionate use only for the left eye. The optical coherence tomography imaging (OCT) showed an improvement of the maculopathy for both patients with a significant improvement in the visual acuity of the treated eye compared to the controlateral one. Our results suggest that the rMnSOD gel formulation exerts a therapeutic action on macular degeneration.

Citation

Grumetto, L., Prete, A. D., Russo, G., Borrelli, A., Del Prete, S., & Mancini, A. (2017). Improvement of Retinal Function after Administration of an Ophthalmic Gel Containing a New Recombinant form of Superoxide Dismutase. IL Journal of Clinical Case Reports, 1(1), 1-5

• Journal Article Type: Article
• Acceptance Date: Sep 1, 2017
• Online Publication Date: Sep 4, 2017
• Publication Date: 2017
• Deposit Date: May 4, 2020
• Journal: IL Journal of Clinical Case Reports
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 1
• Pages: 1-5
• Keywords: Eye; Retina; maculopthy; Superoxide dismutase
• Public URL: http://researchrepository.napier.ac.uk/Output/2658218