D Ashley Robinson
Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone
Robinson, D Ashley; Kearns, Angela M; Holmes, Anne; Morrison, Donald; Grundmann, Hajo; Edwards, Giles; O'Brien, Frances G; Tenover, Fred C; McDougal, Linda K; Monk, Alastair B; Enright, Mark C
Authors
Angela M Kearns
Anne Holmes
Dr Donald Morrison D.Morrison2@napier.ac.uk
Lecturer
Hajo Grundmann
Giles Edwards
Frances G O'Brien
Fred C Tenover
Linda K McDougal
Alastair B Monk
Mark C Enright
Abstract
During the 1950s, the notorious penicillin-resistant clone of Staphylococcus aureus known as phage type 80/81 emerged and caused serious hospital-acquired and community-acquired infections worldwide. This clone was largely eliminated in the 1960s, concurrent with the widespread use of penicillinase-resistant beta lactams. We investigated whether early 80/81 isolates had the genes for Panton-Valentine leucocidin, a toxin associated with virulence in healthy young people. Multilocus sequence analysis suggested that descendants of 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital-acquired MRSA.
Journal Article Type | Article |
---|---|
Publication Date | 2005-04 |
Deposit Date | Jun 12, 2015 |
Print ISSN | 0140-6736 |
Electronic ISSN | 1474-547X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 365 |
Issue | 9466 |
Pages | 1256-1258 |
DOI | https://doi.org/10.1016/S0140-6736%2805%2974814-5 |
Keywords | Staphylococcus aureus; phage type 80/81; hospital-acquired and community-acquired infections; penicillinase-resistant β lactams; MRSA: |
Public URL | http://researchrepository.napier.ac.uk/id/eprint/8676 |
Publisher URL | http://dx.doi.org/10.1016/S0140-6736(05)74814-5 |
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