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Clonal selection from first principles.

McEwan, Chris; Hart, Emma


Chris McEwan


Chris McEwan

Jon Timmis

Andy Hone


Clonal selection is the keystone of mainstream immunology
and computational systems based on immunological principles. For the
latter, clonal selection is often interpreted as an asexual variant of natural
selection, and thus, tend to be variations on evolutionary strategies.
Retro-fitting immunological sophistication and theoretical rigour onto
such systems has proved to be unwieldy. In this paper we assert the
primacy of competitive exclusion over selection and mutation; providing
theoretical analysis and empirical results that support our position.
We show our algorithm to be highly competitive with well-established
approximationandlearningtechniques;notablyfor large,high-dimensional
problems. We further argue that it provides concise, operational abstractions
of some influential theoretical immunology.

Start Date Jul 26, 2010
End Date Jul 29, 2010
Publication Date 2010
Deposit Date Feb 4, 2011
Publicly Available Date Feb 4, 2011
Peer Reviewed Peer Reviewed
Pages 18-32
Series Title Lecture Notes in Computer Science
Series Number 6209
Series ISSN 0302-9743
Book Title Artificial Immune Systems, Proceedings of 9th International Conference, ICARIS 2010
ISBN 978-3-642-14546-9
Keywords Clonal selection; theoretical immunology; competitive exclusion;
Public URL
Publisher URL
Contract Date Feb 4, 2011


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