Clonal selection from first principles.

McEwan, Chris; Hart, Emma

Abstract

Clonal selection is the keystone of mainstream immunology
and computational systems based on immunological principles. For the
latter, clonal selection is often interpreted as an asexual variant of natural
selection, and thus, tend to be variations on evolutionary strategies.
Retro-fitting immunological sophistication and theoretical rigour onto
such systems has proved to be unwieldy. In this paper we assert the
primacy of competitive exclusion over selection and mutation; providing
theoretical analysis and empirical results that support our position.
We show our algorithm to be highly competitive with well-established
approximationandlearningtechniques;notablyfor large,high-dimensional
problems. We further argue that it provides concise, operational abstractions
of some influential theoretical immunology.

Citation

McEwan, C., & Hart, E. (2010, July). Clonal selection from first principles

• Start Date: Jul 26, 2010
• End Date: Jul 29, 2010
• Publication Date: 2010
• Deposit Date: Feb 4, 2011
• Publicly Available Date: Feb 4, 2011
• Peer Reviewed: Peer Reviewed
• Pages: 18-32
• Series Title: Lecture Notes in Computer Science
• Series Number: 6209
• Series ISSN: 0302-9743
• Book Title: Artificial Immune Systems, Proceedings of 9th International Conference, ICARIS 2010
• ISBN: 978-3-642-14546-9
• DOI: https://doi.org/10.1007/978-3-642-14547-6_3
• Keywords: Clonal selection; theoretical immunology; competitive exclusion
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/3878
• Contract Date: Feb 4, 2011