The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression

Ross, Mark; Malone, Eva; Simpson, Richard; Florida-James, Geraint

Abstract

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Regular exercise is known to offset the age-related decline in blood vessel number and function; however the mechanisms are not yet fully understood. Circulating angiogenic cells are known to play important role in vascular repair. The role of age and CRF on a subset of these cells; angiogenic T cells (TANG), is not yet understood.
PURPOSE: To determine the influence of age and cardiorespiratory fitness (CRF) on TANG.
METHODS: CRF was estimated in 62 male participants aged 18-65 through the use of a submaximal cycling ergometer test (YMCA). TANG were quantified by flow cytometry in a resting blood sample, defined as co-expression of CD3 and CD31. In addition to cell number, expression of C-X-C Chemokine Receptor 4 (CXCR4) was also quantified as an indicator of migratory capacity. Linear regressions were performed to examine association between TANG and age, and CRF individually, and where appropriate, step-wise comparisons were made. Comparisons were made between young (50 yrs) men, in addition to fitness subcategories (low CRF and high CRF). Age and CRF comparisons were made using two-way Analysis of Variance (ANOVA). RESULTS: Age was inversely associated with TANG number (r=-0.337, p

Citation

Ross, M., Malone, E., Simpson, R., & Florida-James, G. (2015, May). The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression. Poster presented at American College of Sports Medicine (ACSM) Annual Congress

• Presentation Conference Type: Poster
• Conference Name: American College of Sports Medicine (ACSM) Annual Congress
• Start Date: May 27, 2015
• End Date: May 30, 2015
• Deposit Date: Apr 18, 2018
• Keywords: Ageing, physical activity, fitness,
• Public URL: http://researchrepository.napier.ac.uk/Output/1155873