Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection
(2012)
Journal Article
Rodríguez-Martín, S., Kropp, K. A., Wilhelmi, V., Lisnic, V. J., Hsieh, W. Y., Blanc, M., Livingston, A., Busche, A., Tekotte, H., Messerle, M., Auer, M., Fraser, I., Jonjic, S., Angulo, A., Reddehase, M. J., Ghazal, P., & Britt, W. J. (2012). Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection. PLOS Pathogens, 8(8), Article e1002901. https://doi.org/10.1371/journal.ppat.1002901
Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In... Read More about Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection.