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P1‐274: Ageing increases vulnerability to Aβ42 toxicity in drosophila (2012)
Presentation / Conference Contribution
Kerr, F., Rogers, I., Martinez, P., Hardy, J., Lovestone, S., & Partridge, L. (2012, July). P1‐274: Ageing increases vulnerability to Aβ42 toxicity in drosophila. Presented at Alzheimer 's Association International Conference 2012, Vancouver, British Columbia

Background
Ageing is the major risk factor for the development of many neurodegenerative diseases, including Alzheimer's Disease (AD). One of the major unresolved questions in the AD field asks why neurodegeneration occurs late in life. This associa... Read More about P1‐274: Ageing increases vulnerability to Aβ42 toxicity in drosophila.

Five-year follow-up of participants in a randomised controlled trial showing benefits from exercise for breast cancer survivors during adjuvant treatment. Are there lasting effects? (2012)
Journal Article
Mutrie, N., Campbell, A., Barry, S., Hefferon, K., McConnachie, A., Ritchie, D., & Tovey, S. (2012). Five-year follow-up of participants in a randomised controlled trial showing benefits from exercise for breast cancer survivors during adjuvant treatment. Are there lasting effects?. Journal of Cancer Survivorship, 6(4), 420-430. https://doi.org/10.1007/s11764-012-0233-y

In an earlier randomised controlled trial, we showed that early stage breast cancer patients who received a supervised exercise programme, with discussion of behaviour change techniques, had psychological and functional benefits 6 months after the in... Read More about Five-year follow-up of participants in a randomised controlled trial showing benefits from exercise for breast cancer survivors during adjuvant treatment. Are there lasting effects?.

An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials (2012)
Journal Article
Kermanizadeh, A., Gaiser, B. K., Hutchison, G. R., & Stone, V. (2012). An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials. Particle and fibre toxicology, 9(1), 28. https://doi.org/10.1186/1743-8977-9-28

Background:
Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study... Read More about An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials.

Evaluation of the impact and control of enzootic abortion of ewes (2012)
Journal Article
Longbottom, D., Entrican, G., Wheelhouse, N., Brough, H., & Milne, C. (2013). Evaluation of the impact and control of enzootic abortion of ewes. Veterinary Journal, 195(2), 257-259. https://doi.org/10.1016/j.tvjl.2012.06.018

Despite the availability of effective management and treatment strategies, Chlamydia abortus remains the single most frequently diagnosed cause of infectious ovine abortion (enzootic abortion of ewes, EAE) in the UK and one of the most significant ca... Read More about Evaluation of the impact and control of enzootic abortion of ewes.

In silico analysis of bacteriophage E3 infecting the pathogen Rhodococcus equi: evolutionary relationships to mycobacterial Myoviridae (2012)
Presentation / Conference Contribution
Foley, S., Salifu, S. P., Valero-Rello, A., Campbell, S. A., Inglis, N. F., Scortti, M., & Vázquez-Boland, J. A. (2012, July). In silico analysis of bacteriophage E3 infecting the pathogen Rhodococcus equi: evolutionary relationships to mycobacterial Myoviridae. Poster presented at Viruses of Microbes Conference, Brussels, Belgium

Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila (2012)
Journal Article
Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S., & Partridge, L. (2012). Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila. PLOS ONE, 7(7), Article e40569. https://doi.org/10.1371/journal.pone.0040569

Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's Disease (AD), for reasons that are not clear. The association could indicate that the duration or degree of exposure to toxic proteins is important for pathology,... Read More about Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila.

MEPE is a novel regulator of growth plate cartilage mineralization (2012)
Journal Article
Staines, K. A., Mackenzie, N. C. W., Clarkin, C. E., Zelenchuk, L., Rowe, P. S., MacRae, V. E., & Farquharson, C. (2012). MEPE is a novel regulator of growth plate cartilage mineralization. Bone, 51(3), 418-430. https://doi.org/10.1016/j.bone.2012.06.022

Matrix extracellular phosphoglycoprotein (MEPE) belongs to the SIBLING protein family which play key roles in biomineralization. Although the growth plates of MEPE-overexpressing mice display severe morphological disruption, the expression and functi... Read More about MEPE is a novel regulator of growth plate cartilage mineralization.